3-Chlorophenylmagnesium bromide
3-Chlorophenylmagnesium bromide (CAS: 36229-42-2), with the empirical formula C6H4BrClMg and a molecular weight of 215.76 g/mol, is a valuable organometallic reagent. It is typically supplied as a 0.5 M solution in Tetrahydrofuran (THF). This Grignard reagent is primarily employed in organic synthesis as a nucleophile for introducing the 3-chlorophenyl group into various molecular structures. Its reactivity makes it a key intermediate in the preparation of more complex organic compounds.
Organic Synthesis Intermediate
3-Chlorophenylmagnesium bromide serves as a versatile building block in the synthesis of complex organic molecules. It facilitates carbon-carbon bond formation through reactions with electrophiles such as aldehydes, ketones, and esters.
Pharmaceutical Intermediate
This Grignard reagent can be utilized in the development pathways of pharmaceutical compounds. Its incorporation into molecular scaffolds can lead to novel drug candidates or known active pharmaceutical ingredients.
Agrochemical Synthesis
The 3-chlorophenyl moiety is found in certain agrochemicals. 3-Chlorophenylmagnesium bromide offers a direct route for incorporating this structural element during the manufacturing process of pesticides or herbicides.
Material Science
Organometallic reagents like 3-Chlorophenylmagnesium bromide can be used in the synthesis of specialized polymers or organic materials with unique electronic or physical properties.
| Molecular weight | 215.76 |
|---|---|
| Empirical formula | C6H4BrClMg |
| Boiling point | 65 °C(lit.) |
| Density | 0.960 g/mL at 25 °C(lit.) |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chlorophenylmagnesium bromide used for?
+
3-Chlorophenylmagnesium bromide is primarily used in organic synthesis as a nucleophile for introducing the 3-chlorophenyl group into organic molecules, serving as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals.
What is the CAS number and molecular formula for 3-Chlorophenylmagnesium bromide?
+
The CAS number for 3-Chlorophenylmagnesium bromide is 36229-42-2, and its empirical formula (Hill notation) is C6H4BrClMg.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-Chlorophenylmagnesium bromide as a 0.5 M solution in Tetrahydrofuran (THF). This is typically considered a technical or research grade. Tech Serve Solutions does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
What are the safety and handling considerations for 3-Chlorophenylmagnesium bromide?
+
3-Chlorophenylmagnesium bromide is a highly flammable liquid and vapour (H225). It causes serious eye irritation (H319) and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351). It may form explosive peroxides and should be stored under an inert atmosphere in a cool, well-ventilated area, away from ignition sources. Always use appropriate personal protective equipment.
How is 3-Chlorophenylmagnesium bromide packed and shipped?
+
3-Chlorophenylmagnesium bromide is classified under UN 2924, Packing Group II, for transport. It is shipped according to relevant dangerous goods regulations. Standard packaging for organometallic solutions is used to ensure stability and safety during transit.
How can I request a sample or quote for 3-Chlorophenylmagnesium bromide?
+
To request a sample or a quote for 3-Chlorophenylmagnesium bromide, please use the 'Request a Quote' or 'Sample Request' form on our website, or contact our sales department directly via email or phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis