3,5-Bis(trifluoromethyl)benzoyl chloride
3,5-Bis(trifluoromethyl)benzoyl chloride (CAS: 785-56-8) is an organic acid halide featuring two trifluoromethyl groups. With a molecular weight of 276.56 g/mol, this compound serves as a valuable building block in organic synthesis. Its primary documented application involves its use in the quantitative assay of clonidine in biological samples, highlighting its utility in analytical chemistry and pharmaceutical research.
- Synonyms
- (CF3)2C6H3COCl
Analytical Reagent
3,5-Bis(trifluoromethyl)benzoyl chloride is employed as a derivatising agent in analytical methods. It has been specifically used for the quantitative and selective assay of clonidine in human plasma, enabling precise measurement of low drug concentrations.
Organic Synthesis Intermediate
As an acid halide with two electron-withdrawing trifluoromethyl groups, this compound is a useful intermediate in organic synthesis. It can participate in reactions to introduce the 3,5-bis(trifluoromethyl)benzoyl moiety into various organic structures.
Building Block for Specialty Chemicals
The unique structure of 3,5-bis(trifluoromethyl)benzoyl chloride makes it a key building block for the synthesis of more complex molecules, including potential pharmaceutical candidates and materials with specific electronic properties.
| Molecular weight | 276.56 |
|---|---|
| Linear formula | (CF3)2C6H3COCl |
| Assay | 97% |
| Density | 1.526 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.435(lit.) |
| Application | 3,5-Bis(trifluoromethyl)benzoyl chloride was used in the quantitative and selective assay for the measurement of low levels of clonidine in human plasma1. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 72 °C / 161.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Bis(trifluoromethyl)benzoyl chloride used for?
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3,5-Bis(trifluoromethyl)benzoyl chloride is used as an analytical reagent, particularly for derivatisation in the quantitative assay of clonidine in human plasma. It also serves as a valuable building block in organic synthesis for creating more complex molecules.
What is the CAS number and formula for 3,5-Bis(trifluoromethyl)benzoyl chloride?
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The CAS number is 785-56-8, and its linear formula is (CF3)2C6H3COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Bis(trifluoromethyl)benzoyl chloride with an assay of 97%. This is a technical/research grade product and is not represented as USP, BP, or EP grade.
What are the main hazards associated with 3,5-Bis(trifluoromethyl)benzoyl chloride?
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This compound is classified as Danger, with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including face shields, gloves, and respirators, must be used. It is also irritating to the respiratory system (H37/R37).
How is 3,5-Bis(trifluoromethyl)benzoyl chloride shipped and exported?
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3,5-Bis(trifluoromethyl)benzoyl chloride is shipped as a UN 3265 (Class 8, PG II) hazardous material. Tech Serve Solutions is experienced in global export of fine chemicals, adhering to all relevant transport regulations.
How can I request a quote or sample for 3,5-Bis(trifluoromethyl)benzoyl chloride?
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To request a quote or sample, please use the contact form on our website or call our sales department, referencing product CAS 785-56-8.
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