3,4-Difluorobenzoyl chloride
3,4-Difluorobenzoyl chloride (CAS: 76903-88-3) is a fluorinated organic building block with the linear formula F2C6H3COCl and a molecular weight of 176.55 g/mol. This acid halide is primarily utilised in chemical synthesis, serving as a valuable intermediate for introducing the 3,4-difluorobenzoyl moiety into various organic molecules. Its reactive nature makes it suitable for diverse synthetic applications where precise fluorination is required.
- Synonyms
- F2C6H3COCl

Organic Synthesis Intermediate
3,4-Difluorobenzoyl chloride is employed as a key intermediate in the synthesis of complex organic molecules. Its structure allows for the introduction of a difluorinated aromatic ring, which is often desired in pharmaceutical and agrochemical research.
Research and Development
Utilised in R&D settings to explore new chemical pathways and create novel compounds. The presence of fluorine atoms can significantly alter the electronic and steric properties of molecules, making it an attractive building block for structure-activity relationship studies.
Specialty Chemical Manufacturing
Serves as a precursor in the production of specialty chemicals, including advanced materials and fine chemicals. Its reactivity as an acyl chloride enables versatile derivatisation.
| Molecular weight | 176.55 |
|---|---|
| Linear formula | F2C6H3COCl |
| Assay | 98% |
| Density | 1.403 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5114(lit.) |
| Application | 3,4-Difluorobenzoyl chloride may be used in chemical synthesis studies. |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 78 °C / 172.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Difluorobenzoyl chloride used for?
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3,4-Difluorobenzoyl chloride is used as an intermediate in chemical synthesis, particularly for introducing the 3,4-difluorobenzoyl group into organic molecules during research and development.
What is the CAS number and formula for 3,4-Difluorobenzoyl chloride?
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The CAS number is 76903-88-3, and the linear formula is F2C6H3COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4-Difluorobenzoyl chloride with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How is 3,4-Difluorobenzoyl chloride handled and shipped?
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3,4-Difluorobenzoyl chloride is classified as corrosive (H314) and requires careful handling. It is shipped according to UN 3265, 8 / PGII regulations. Appropriate personal protective equipment, including gloves, goggles, and face shields, must be used. It is exported globally by Tech Serve Solutions.
How can I request a sample or quote for 3,4-Difluorobenzoyl chloride?
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To request a sample or a quotation, please contact our sales department via the website or by telephone. Our team will be pleased to assist you with your inquiry.
What are the primary hazards associated with 3,4-Difluorobenzoyl chloride?
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3,4-Difluorobenzoyl chloride causes severe skin burns and eye damage (H314). It is a corrosive substance that requires stringent safety precautions during handling and storage.
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