3,4-Difluorobenzyl bromide
3,4-Difluorobenzyl bromide (CAS: 85118-01-0) is a fluorinated organic building block with the linear formula F2C6H3CH2Br and a molecular weight of 207.02 g/mol. This compound serves as a valuable intermediate in organic synthesis, particularly in the development of novel chemical entities. Its applications span various research fields requiring specialised fluorinated aromatic compounds for the construction of complex molecular architectures.
- IUPAC
- α-Bromo-3,4-difluorotoluene
- Synonyms
- F2C6H3CH2Brα-Bromo-3,4-difluorotoluene
Synthesis of Benzothiophene Derivatives
3,4-Difluorobenzyl bromide has been utilised in the synthesis of a series of benzothiophene-based phosphonates, showcasing its utility in constructing heterocyclic systems with potential pharmaceutical relevance.
Fluorinated Building Block
As a difluorinated benzyl halide, this compound is a key building block for introducing fluorinated benzyl moieties into organic molecules. This is important in medicinal chemistry and materials science where fluorine substitution can significantly alter a molecule's properties.
Organic Synthesis Intermediate
It functions as a reactive intermediate in various coupling and substitution reactions. The bromide leaving group allows for facile reaction with nucleophiles, enabling the formation of new carbon-carbon or carbon-heteroatom bonds.
| Molecular weight | 207.02 |
|---|---|
| Linear formula | F2C6H3CH2Br |
| Assay | 98% |
| Density | 1.618 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.526(lit.) |
| Application | 3,4-Difluorobenzyl bromide has been used in the synthesis of series of benzothiophene-based phosphonates1. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 79 °C / 174.2 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Difluorobenzyl bromide used for?
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3,4-Difluorobenzyl bromide is primarily used as a building block and intermediate in organic synthesis, notably in the preparation of benzothiophene-based phosphonates and other fluorinated organic compounds.
What is the CAS number and formula for 3,4-Difluorobenzyl bromide?
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The CAS number is 85118-01-0, and its linear formula is F2C6H3CH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4-Difluorobenzyl bromide with a minimum assay of 98%. This product is not classified as USP, BP, or EP grade and is intended for research and chemical synthesis purposes.
How should 3,4-Difluorobenzyl bromide be handled?
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3,4-Difluorobenzyl bromide is classified as corrosive and may cause respiratory irritation. It requires careful handling with appropriate personal protective equipment, including chemical-resistant gloves, eye protection (goggles and face shield), and respiratory protection. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
How is 3,4-Difluorobenzyl bromide packed and shipped?
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As per UN 3265 regulations, 3,4-Difluorobenzyl bromide is packed in suitable containers for corrosive solids, acidic, organic, not otherwise specified, and shipped internationally according to relevant hazardous materials transport guidelines.
How can I request a quote or sample for 3,4-Difluorobenzyl bromide?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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