2-(Trimethylsilyl)ethanol

CAS 2916-68-9(CH3)3SiCH2CH2OHChemical Synthesis

2-(Trimethylsilyl)ethanol (CAS 2916-68-9), with the linear formula (CH3)3SiCH2CH2OH and a molecular weight of 118.25 g/mol, is a versatile silicon-based reagent. Its primary utility lies in organic synthesis as a protecting group for carboxyl and phosphate functionalities. Supplied by TSS, this compound is instrumental in multi-step synthesis where selective protection and deprotection are critical.

IUPAC: (2-Hydroxyethyl)trimethylsilane

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2-(Trimethylsilyl)ethanol ((CH3)3SiCH2CH2OH) — chemical structure, CAS 2916-68-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisSilicon-BasedSynthetic Reagents

01 /Applications

Protecting Group for Carboxyl Groups

2-(Trimethylsilyl)ethanol serves as an effective reagent for the protection of carboxylic acids. This protection strategy is valuable in complex organic synthesis pathways, enabling selective reactions elsewhere in the molecule.

Protecting Group for Phosphate Groups

This silylating agent is also employed to protect phosphate groups in various chemical transformations. Its application is crucial in nucleoside and nucleotide chemistry, where precise control over reactivity is essential.

Chemical Synthesis Reagent

As a broader synthetic reagent, 2-(Trimethylsilyl)ethanol finds use in diverse organic chemistry applications. Its silicon-based structure offers unique reactivity and stability profiles for specialised synthetic needs.

02 /Properties

Molecular weight	118.25
Linear formula	(CH3)3SiCH2CH2OH
Assay	99%
Boiling point	71-73 °C/35 mmHg(lit.)
Density	0.825 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.423(lit.)
Application	Protecting reagent for carboxyl1 and phosphate2,3,4 groups.

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Warning

Hazard statements

H226Flammable liquid and vapour

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	56 °C / 132.8 °F
Transport (UN / ADR)	UN 1987C 3 / PGIII
Water hazard class (WGK, DE)	3
Risk statements (R)	10
Safety statements (S)	16

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2916-68-9

MDL number

MFCD00002825

PubChem substance

24853596

Beilstein registry

1732034

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-(Trimethylsilyl)ethanol used for?

2-(Trimethylsilyl)ethanol is primarily used as a protecting reagent for carboxyl and phosphate groups in organic synthesis.

What is the CAS number and formula for 2-(Trimethylsilyl)ethanol?

The CAS number for 2-(Trimethylsilyl)ethanol is 2916-68-9, and its linear formula is (CH3)3SiCH2CH2OH.

What grade and purity does Tech Serve Solutions supply for 2-(Trimethylsilyl)ethanol?

Tech Serve Solutions supplies 2-(Trimethylsilyl)ethanol with an assay of 99%. TSS does not represent this product as USP, BP, or EP grade.

How should 2-(Trimethylsilyl)ethanol be handled safely?

2-(Trimethylsilyl)ethanol is a flammable liquid and vapour (H226). Handle with appropriate personal protective equipment, including eyeshields, gloves, and in a well-ventilated area or with a suitable respirator, away from ignition sources.

Is 2-(Trimethylsilyl)ethanol shipped internationally by TSS?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-(Trimethylsilyl)ethanol, adhering to all relevant shipping regulations.