2-(Trimethylsilyl)ethoxymethyl chloride
2-(Trimethylsilyl)ethoxymethyl chloride (CAS 76513-69-4), with the linear formula (CH3)3SiCH2CH2OCH2Cl and a molecular weight of 166.72, is a silicon-based synthetic reagent. It is primarily utilised as a protecting group for phenols in organic synthesis. This compound is supplied by Tech Serve Solutions for research and development applications, offering a reliable option for chemical transformations requiring specific protection strategies.
- IUPAC
- (2-Chloromethoxyethyl)trimethylsilane,Chloromethyl 2-trimethylsilylethyl ether,SEM-Cl,SEM-chloride
- Synonyms
- (2-Chloromethoxyethyl)trimethylsilaneSEM-ClSEM-chlorideChloromethyl 2-trimethylsilylethyl ether
Phenol Protection
2-(Trimethylsilyl)ethoxymethyl chloride serves as an effective protecting group for phenolic hydroxyl groups. This application is crucial in multi-step organic syntheses where selective protection is required to prevent unwanted reactions at the phenol moiety.
Synthesis of Laterifluorones
This reagent has been specifically documented for its role in the synthesis of laterifluorones. Its ability to selectively protect phenols enables the controlled construction of complex molecular architectures.
Organic Synthesis Reagent
As a silicon-based compound, it functions as a versatile reagent in various organic transformations. Its unique structure allows for controlled deprotection under specific conditions, making it valuable in complex synthetic routes.
| Molecular weight | 166.72 |
|---|---|
| Linear formula | (CH3)3SiCH2CH2OCH2Cl |
| Assay | ≥95.0% (GC) |
| Boiling point | 170-172 °C(lit.)57-59 °C/8 mmHg(lit.) |
| Density | 0.942 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.435(lit.)n20/D 1.436 |
| Storage temperature | 2-8°C |
| Application | Phenol protecting group in the synthesis of laterifluorones.1 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 46 °C / 114.8 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trimethylsilyl)ethoxymethyl chloride used for?
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2-(Trimethylsilyl)ethoxymethyl chloride is primarily used as a protecting group for phenols in organic synthesis, notably in the synthesis of laterifluorones.
What is the CAS number and formula for 2-(Trimethylsilyl)ethoxymethyl chloride?
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The CAS number is 76513-69-4 and the linear formula is (CH3)3SiCH2CH2OCH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Trimethylsilyl)ethoxymethyl chloride with an assay of ≥95.0% (GC). It is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-(Trimethylsilyl)ethoxymethyl chloride be handled safely?
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This compound is classified as corrosive and flammable. Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection. Ensure adequate ventilation and avoid ignition sources. Refer to the Safety Data Sheet (SDS) for comprehensive handling guidelines.
Is 2-(Trimethylsilyl)ethoxymethyl chloride a controlled substance?
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Based on the provided data, 2-(Trimethylsilyl)ethoxymethyl chloride is not indicated as a controlled substance.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packages and ships chemicals in compliance with all relevant transportation regulations. As a global supplier, we export fine chemicals worldwide, adhering to international shipping standards.
How can I request a sample or quote for 2-(Trimethylsilyl)ethoxymethyl chloride?
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To request a sample or a quotation, please contact our sales team through the designated channels on the Tech Serve Solutions website, providing the product name and CAS number.
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