2-(Trifluoromethyl)benzyl chloride
2-(Trifluoromethyl)benzyl chloride (CAS 21742-00-7, CF3C6H4CH2Cl) is a halogenated aromatic compound with a molecular weight of 194.58. This chemical serves as a valuable building block in organic synthesis. It is particularly useful in the preparation of more complex molecules, including heterocyclic compounds, through various chemical transformations. Its reactivity makes it a key intermediate in research and development across multiple chemical disciplines.
- IUPAC
- α′-Chloro-α,α,α-trifluoro-o-xylene
Synthesis of Heterocyclic Compounds
2-(Trifluoromethyl)benzyl chloride is employed in the construction of complex fused ring systems. For instance, it reacts with organolithium reagents to form novel thiophene derivatives, such as 6-fluorobenzo[b]naphtho[2,3-d]thiophene.
Organic Building Block
This compound functions as a versatile intermediate in academic and industrial research. Its trifluoromethyl and benzyl chloride moieties offer distinct reactive sites for further chemical modifications and elaborations.
Chemical Research and Development
Utilised in the exploration of new synthetic pathways and the development of novel chemical entities. Its structure makes it suitable for introducing the trifluoromethylbenzyl group into various molecular frameworks.
| Molecular weight | 194.58 |
|---|---|
| Linear formula | CF3C6H4CH2Cl |
| Assay | 97% |
| Density | 1.337 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.469(lit.) |
| Application | 2-(Trifluoromethyl)benzyl chloride reacts with 2-benzo[b]thienyllithium to yield 6-fluorobenzo[b]naphtho[2,3-d]thiophene1. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 70 °C / 158 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethyl)benzyl chloride used for?
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2-(Trifluoromethyl)benzyl chloride is primarily used as a building block in organic synthesis, particularly for creating complex heterocyclic compounds and as an intermediate in chemical research and development.
What are the CAS number and formula for 2-(Trifluoromethyl)benzyl chloride?
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The CAS number for 2-(Trifluoromethyl)benzyl chloride is 21742-00-7, and its linear formula is CF3C6H4CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Trifluoromethyl)benzyl chloride with an assay of 97%. This is a technical or research grade chemical, and TSS does not represent it as USP, BP, or EP grade.
How should 2-(Trifluoromethyl)benzyl chloride be handled safely?
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Due to its hazardous properties (causes severe skin burns and eye damage; may cause respiratory irritation), handle with extreme caution. Use full personal protective equipment including gloves, goggles, faceshields, and appropriate respiratory protection. Work in a well-ventilated area. Refer to the safety data sheet for detailed guidance.
Is 2-(Trifluoromethyl)benzyl chloride a controlled substance?
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The provided data does not indicate that 2-(Trifluoromethyl)benzyl chloride is a controlled substance.
How is 2-(Trifluoromethyl)benzyl chloride packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions ensures that 2-(Trifluoromethyl)benzyl chloride is packed, shipped, and exported in compliance with all relevant international regulations for hazardous materials, including UN 3265 classification.
How can I request a sample or quote for 2-(Trifluoromethyl)benzyl chloride?
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To request a sample or a quote for 2-(Trifluoromethyl)benzyl chloride, please contact our sales team through the website or via the provided contact details.
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