2-(Trifluoromethoxy)benzenesulfonyl chloride
2-(Trifluoromethoxy)benzenesulfonyl chloride (CAS: 103008-51-1, Formula: CF3OC6H4SO2Cl) is a key organic building block with a molecular weight of 260.62 g/mol. This compound serves as a versatile intermediate in chemical synthesis, particularly for introducing the trifluoromethoxybenzenesulfonyl moiety into complex molecules. It is essential for researchers and manufacturers in fields requiring advanced organic chemistry.

Organic Synthesis Intermediate
Utilised as a building block in the synthesis of novel organic compounds. Its sulfonyl chloride group readily reacts with nucleophiles, enabling the formation of sulfonamides, sulfonates, and other sulfur-containing derivatives.
Pharmaceutical Research
Serves as a reagent in the development of new pharmaceutical candidates. The trifluoromethoxy group can influence lipophilicity and metabolic stability, properties often desirable in drug discovery.
Agrochemical Development
Employed in the synthesis of potential agrochemicals, where the unique electronic properties of the trifluoromethoxy group can impart desired bioactivity.
| Molecular weight | 260.62 |
|---|---|
| Linear formula | CF3OC6H4SO2Cl |
| Assay | 97% |
| Boiling point | 75-77 °C/1 mmHg(lit.) |
| Melting point | 27-31 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethoxy)benzenesulfonyl chloride used for?
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2-(Trifluoromethoxy)benzenesulfonyl chloride is primarily used as a versatile building block and intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research and development.
What is the CAS number and chemical formula for this product?
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The CAS number is 103008-51-1 and the chemical formula is CF3OC6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Trifluoromethoxy)benzenesulfonyl chloride with an assay of 97%. This product is not represented as USP, BP, or EP grade.
How should 2-(Trifluoromethoxy)benzenesulfonyl chloride be handled?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including goggles, gloves, and a faceshield. Ensure adequate ventilation and use a suitable respirator. Refer to the Safety Data Sheet for detailed handling procedures.
How is this chemical packed and exported?
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2-(Trifluoromethoxy)benzenesulfonyl chloride is packed in compliance with regulations for shipping hazardous materials, including UN 3261, Class 8, Packing Group II. TSS offers global export services.
How can I request a quote or sample?
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To request a quote or sample of 2-(Trifluoromethoxy)benzenesulfonyl chloride, please contact our sales team through the website or by phone, providing your specific requirements.
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