2-(Trifluoroacetyl)thiophene
2-(Trifluoroacetyl)thiophene (CAS: 651-70-7), with the chemical formula C6H3F3OS and a molecular weight of 180.15 g/mol, is a fluorinated heterocyclic ketone. This compound serves as a valuable building block in organic synthesis, particularly for introducing trifluoroacetyl and thiophene moieties into more complex molecules. Its applications span chemical research and the development of novel compounds.

Organic Synthesis Intermediate
2-(Trifluoroacetyl)thiophene is a versatile intermediate used in the synthesis of various organic compounds. Its trifluoroacetyl group offers unique reactivity for subsequent chemical transformations.
Heterocyclic Chemistry
As a thiophene derivative, this compound is employed in the construction of novel heterocyclic systems. These structures are often of interest in medicinal chemistry and material science.
Fluorinated Compound Synthesis
The presence of the trifluoromethyl group makes it a useful precursor for creating more complex fluorinated molecules, which are of significant interest in pharmaceuticals and agrochemicals.
| Molecular weight | 180.15 |
|---|---|
| Empirical formula | C6H3F3OS |
| Assay | 98% |
| Boiling point | 163-165 °C(lit.) |
| Density | 1.403 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.486(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 59 °C / 138.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoroacetyl)thiophene used for?
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2-(Trifluoroacetyl)thiophene is primarily used as a building block in organic synthesis and for the development of novel heterocyclic and fluorinated compounds.
What is the CAS number and chemical formula for 2-(Trifluoroacetyl)thiophene?
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The CAS number is 651-70-7 and the chemical formula is C6H3F3OS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Trifluoroacetyl)thiophene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-(Trifluoroacetyl)thiophene be handled safely?
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2-(Trifluoroacetyl)thiophene is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields and gloves, in a well-ventilated area. Refer to the safety data sheet for full details.
Does Tech Serve Solutions export 2-(Trifluoroacetyl)thiophene?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-(Trifluoroacetyl)thiophene, and can cater to international requirements.
How can I request a quote or sample for 2-(Trifluoroacetyl)thiophene?
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To request a quote or a sample of 2-(Trifluoroacetyl)thiophene, please contact our sales team through the website or by phone, providing your specific requirements.
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