2-Thiohydantoin
2-Thiohydantoin (CAS 503-87-7), with the molecular formula C3H4N2OS and a molecular weight of 116.14 g/mol, is a heterocyclic compound primarily utilised as a reactant in organic synthesis. It serves as a key building block for creating various complex molecules, notably including potential pharmaceutical agents and compounds with demonstrated biological activities. Its specific structure lends itself to diverse chemical transformations, making it valuable in research and development settings.
- IUPAC
- 2-Thioxo-4-imidazolidinone,NSC 11772
Synthesis of Antidiabetic Agents
2-Thiohydantoin acts as a precursor in the synthesis of drugs exhibiting antidiabetic activity. Its reactive sites allow for the construction of molecular scaffolds relevant to metabolic disease research.
Development of Antimicrobial Compounds
It is employed as a reactant in the preparation of barbituric acid and thiohydantoin derivatives that possess antimicrobial properties, contributing to the search for new anti-infective agents.
Precursor for Anticancer Agents
Research indicates its use as a starting material for synthesising compounds with potential anticancer activity, highlighting its role in oncology drug discovery efforts.
Kinase Inhibitor Synthesis
This compound is utilised in the synthesis of fibroblast growth factor receptor 1 kinase inhibitors, which are investigated for their therapeutic potential in various diseases.
HIV-1 Integrase Inhibitor Research
2-Thiohydantoin serves as a reactant in the development pathway for HIV-1 integrase inhibitors, contributing to antiviral research programmes.
| Molecular weight | 116.14 |
|---|---|
| Empirical formula | C3H4N2OS |
| Assay | 99% |
| Vapour density | 4 (vs air) |
| Application | Reactant for synthesis of:• Drugs with antidiabetic activity1• Barbituric acid and thiohydantoin derivatives with antimicrobial activity2• Possible anticancer agents3• Fibroblast growth factor receptor 1 kinase inhibitors4• HIV-1 integrase inhibitors5Reactant for persilylation6 |
| Melting point | 229-231 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Thiohydantoin primarily used for?
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2-Thiohydantoin (CAS 503-87-7) is primarily used as a reactant and building block in organic synthesis for creating various compounds, including potential pharmaceutical agents with antidiabetic, antimicrobial, and anticancer activities, as well as kinase and integrase inhibitors.
What are the CAS number and molecular formula for 2-Thiohydantoin?
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The CAS number for 2-Thiohydantoin is 503-87-7, and its empirical formula is C3H4N2OS.
What grade and purity does Tech Serve Solutions supply for 2-Thiohydantoin?
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Tech Serve Solutions supplies 2-Thiohydantoin with an assay of 99%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 2-Thiohydantoin be handled safely?
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2-Thiohydantoin is harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332). Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, faceshields, and gloves. Ensure adequate ventilation.
Is 2-Thiohydantoin available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Thiohydantoin.
How can I request a quote or sample for 2-Thiohydantoin?
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To request a quote or sample, please contact our sales team via the website or by phone, providing the product name (2-Thiohydantoin) and CAS number (503-87-7).
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