2-Thiopheneacetyl chloride
2-Thiopheneacetyl chloride (CAS: 39098-97-0), with the empirical formula C6H5ClOS and a molecular weight of 160.62 g/mol, is a key heterocyclic building block. This reactive acyl chloride is instrumental in organic synthesis, facilitating the introduction of the 2-thiopheneacetyl moiety into various molecular structures. It is primarily utilised in the research and development of novel pharmaceutical intermediates and fine chemicals.
- IUPAC
- 2-Thienylacetyl chloride
Synthesis of Immunopotentiators
Used in the preparation of immunopotentiators, such as (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, which incorporates a nipecotate-containing structure.
Development of Prodrugs
Serves as a precursor in the synthesis of prodrugs, exemplified by its application in creating 5-fluorouracil-cephalosporin prodrugs.
Preparation of Diamine Derivatives
Involved in the synthesis of a series of new N,N′-di(thiopheneacetyl)diamine derivatives, contributing to the exploration of novel chemical entities.
Construction of Morphine Analogues
Applied in the synthesis of modified morphine structures, such as 6-β-(thiophen-2′-yl)acetamidomorphine, for research purposes.
| Molecular weight | 160.62 |
|---|---|
| Empirical formula | C6H5ClOS |
| Assay | 98% |
| Boiling point | 105-106 °C/22 mmHg(lit.)130-135 °C/90 mmHg(lit.) |
| Density | 1.303 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.551(lit.) |
| Vapour pressure | 4 mmHg (83 °C) |
| Storage temperature | 2-8°C |
| Application | 2-Thiopheneacetyl chloride was used in the synthesis of:• (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator1• 5-fluorouracil-cephalosporin prodrug2• series of new N,N′-di(thiopheneacetyl)diamines derivatives3• 6-β-(thiophen-2′-yl)acetamidomorphine4 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 102 °C / 215.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-37 |
| Safety statements (S) | 26-28-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Thiopheneacetyl chloride used for?
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2-Thiopheneacetyl chloride is used as a building block in organic synthesis, particularly for preparing pharmaceutical intermediates and novel chemical compounds.
What are the CAS number and formula for 2-Thiopheneacetyl chloride?
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The CAS number is 39098-97-0, and the empirical formula is C6H5ClOS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Thiopheneacetyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-Thiopheneacetyl chloride be handled safely?
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2-Thiopheneacetyl chloride is corrosive and reacts violently with water. Handle with appropriate personal protective equipment, including gloves, goggles, a faceshield, and a suitable respirator. Avoid contact with water and ensure adequate ventilation. Refer to the Safety Data Sheet for full handling instructions.
How is 2-Thiopheneacetyl chloride packed and shipped?
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2-Thiopheneacetyl chloride is packed and shipped according to international regulations for hazardous materials, including UN 3265. Storage at 2-8°C is recommended.
How can I request a sample or quote for 2-Thiopheneacetyl chloride?
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To request a sample or quote, please contact our sales department via the website or direct email, providing your specific requirements.
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