2-Methoxy-1,3-dioxolane
2-Methoxy-1,3-dioxolane (CAS 19693-75-5) is an organic compound with the molecular formula C4H8O3. Classified as an acetal/ketal/ortho ester, it serves as a valuable building block in organic synthesis. Its properties make it suitable for creating complex molecular structures, particularly in the development of novel chemical entities for research purposes. This compound is supplied by TSS as a high-purity chemical for scientific and industrial applications.
- Synonyms
- C4H8O3

Organic Synthesis
Utilised as a key intermediate in the synthesis of more complex organic molecules, offering a versatile platform for chemical transformations.
HIV Inhibitor Research
Employed in the synthesis of nucleoside derivatives, such as [4,5-bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides, investigated for their potential as HIV inhibitors.
Diastereoisomeric Acetal Synthesis
Used in the preparation of diastereoisomeric cyclic acetals, contributing to the study of stereochemistry and reaction mechanisms.
Chemical Building Block
Serves as a fundamental building block in medicinal chemistry and materials science research, enabling the construction of diverse molecular architectures.
| Molecular weight | 104.10 |
|---|---|
| Empirical formula | C4H8O3 |
| Assay | 99% |
| Boiling point | 129-130 °C(lit.) |
| Density | 1.092 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.409(lit.) |
| Application | 2-Methoxy-1,3-dioxolane was used in the synthesis of :• [4,5-bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides, potential inhibitors of HIV1• diastereoisomeric cyclic acetals2 |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 34 °C / 93.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of 2-Methoxy-1,3-dioxolane?
+
2-Methoxy-1,3-dioxolane is primarily used as a building block in organic synthesis. It has been specifically applied in the creation of potential HIV inhibitors and diastereoisomeric cyclic acetals.
What is the CAS number and formula for 2-Methoxy-1,3-dioxolane?
+
The CAS number for 2-Methoxy-1,3-dioxolane is 19693-75-5, and its molecular formula is C4H8O3.
What is the purity/grade of 2-Methoxy-1,3-dioxolane supplied by TSS?
+
TSS supplies 2-Methoxy-1,3-dioxolane with an assay of 99%. This is a technical/research grade chemical and is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the key safety hazards associated with 2-Methoxy-1,3-dioxolane?
+
2-Methoxy-1,3-dioxolane is a flammable liquid and vapour (H226). It requires appropriate handling procedures, including the use of personal protective equipment such as eyeshields and gloves, and working in well-ventilated areas. Always consult the Safety Data Sheet (SDS) for comprehensive safety information.
How is 2-Methoxy-1,3-dioxolane packed and shipped?
+
2-Methoxy-1,3-dioxolane is packed and shipped according to relevant regulations for flammable liquids, ensuring safe transport and handling during export. Specific packaging details can be provided upon request.
How can I request a quote for 2-Methoxy-1,3-dioxolane?
+
To request a quote for 2-Methoxy-1,3-dioxolane, please contact the TSS sales department directly through our website or provide your inquiry details to our customer service team.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis