2-Fluorothiophenol
2-Fluorothiophenol (CAS: 2557-78-0), with the molecular formula FC6H4SH and a molecular weight of 128.17 g/mol, is a fluorinated aromatic thiol. This compound serves as a valuable building block in organic synthesis, particularly for introducing fluorinated phenylthio moieties into complex molecules. It is utilised in the preparation of various organic intermediates and has applications in research and development within the chemical and pharmaceutical industries.
- IUPAC
- 2-Fluorobenzenethiol
- Synonyms
- 2-Fluorobenzenethiol

Synthesis of Organic Intermediates
2-Fluorothiophenol is employed as a key intermediate in the synthesis of more complex organic molecules. Its structure allows for specific chemical transformations, making it useful in multi-step synthetic routes.
Preparation of Specialty Chemicals
This compound is used in the preparation of specialty chemicals, including precursors for materials science or agrochemical research. The presence of both fluorine and sulfur offers unique reactivity and properties to the final products.
Research and Development
As a fluorinated building block, 2-Fluorothiophenol is utilised in academic and industrial research laboratories for developing novel compounds and exploring new synthetic methodologies.
| Molecular weight | 128.17 |
|---|---|
| Linear formula | FC6H4SH |
| Assay | 97% |
| Boiling point | 61-62 °C/35 mmHg(lit.) |
| Density | 1.2 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.557(lit.) |
| Storage temperature | 2-8°C |
| Application | 2-Fluorothiophenol was used in the synthesis of 2-bromo-2′-fluorodiphenyl sulfide1. |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 47 °C / 116.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluorothiophenol used for?
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2-Fluorothiophenol is used as a building block in organic synthesis, particularly for preparing fluorinated organic intermediates and specialty chemicals.
What is the CAS number and chemical formula for 2-Fluorothiophenol?
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The CAS number is 2557-78-0 and the chemical formula is FC6H4SH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluorothiophenol with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should 2-Fluorothiophenol be handled safely?
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2-Fluorothiophenol is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, faceshields, gloves, and a suitable respirator. Store in a cool place away from heat and ignition sources.
Is 2-Fluorothiophenol flammable?
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Yes, 2-Fluorothiophenol is a flammable liquid and vapour with a flash point of 47 °C (116.6 °F).
How is 2-Fluorothiophenol shipped and exported?
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2-Fluorothiophenol is shipped and exported according to international regulations for hazardous materials, classified under UN 1993, Class 3, Packing Group III.
How can I request a sample or quote for 2-Fluorothiophenol?
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To request a sample or obtain a quotation for 2-Fluorothiophenol, please contact our sales department through the website or via direct inquiry.
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