2-Fluoropyridine-5-boronic acid pinacol ester
2-Fluoropyridine-5-boronic acid pinacol ester (CAS: 444120-95-0) is an organoboron compound with the molecular formula C11H15BFNO2 and a molecular weight of 223.05 g/mol. This versatile building block is frequently employed in organic synthesis, particularly in cross-coupling reactions for the formation of carbon-carbon bonds. Its utility spans the development of novel pharmaceutical agents and advanced materials, owing to the reactive boronate ester moiety and the fluoropyridine core.
- IUPAC
- 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine,2-Fluoro-5-pyridineboronic acid pinacol ester
- Synonyms
- 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine2-Fluoro-5-pyridineboronic acid pinacol ester
Organic Synthesis Reagent
Used as a key intermediate in Suzuki-Miyaura cross-coupling reactions to introduce the 2-fluoropyridin-5-yl group into complex molecules. Facilitates the synthesis of diverse heterocyclic compounds.
Pharmaceutical Intermediate
A crucial building block in the development of novel drug candidates. The fluoropyridine motif is present in various bioactive compounds, making this ester valuable for medicinal chemistry research.
Materials Science
Applicable in the synthesis of functional materials, such as organic light-emitting diodes (OLEDs) and other electronic materials where specific heteroaromatic structures are required.
| Molecular weight | 223.05 |
|---|---|
| Empirical formula | C11H15BFNO2 |
| Assay | ≥95% |
| Melting point | 29-33 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoropyridine-5-boronic acid pinacol ester used for?
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This compound is primarily used as a building block in organic synthesis, especially for Suzuki-Miyaura cross-coupling reactions. It is valuable in the development of pharmaceuticals and advanced materials.
What are the CAS number and formula for this compound?
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The CAS number is 444120-95-0, and the empirical formula is C11H15BFNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoropyridine-5-boronic acid pinacol ester with an assay of ≥95%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
What are the main safety hazards associated with this chemical?
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This compound is classified as a Warning. It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used.
How is 2-Fluoropyridine-5-boronic acid pinacol ester typically packed and shipped?
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This chemical is packed according to industry standards to ensure safe transport. As a global supplier and exporter, Tech Serve Solutions adheres to all relevant shipping regulations.
How can I request a sample or obtain a quote for 2-Fluoropyridine-5-boronic acid pinacol ester?
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To request a sample or obtain a quote, please contact the Tech Serve Solutions sales team through our website or by phone, providing the product name and CAS number (444120-95-0).
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