2-Chloro-4-(trifluoromethyl)pyrimidine
2-Chloro-4-(trifluoromethyl)pyrimidine (CAS: 33034-67-2; Formula: C5H2ClF3N2; Molar Mass: 182.53) is a halogenated heterocyclic building block. This pyrimidine derivative, with its trifluoromethyl and chlorine substituents, is primarily utilised in chemical synthesis for the creation of more complex organic molecules. It serves as a valuable intermediate in the development of novel compounds, particularly within research and development settings for potential pharmaceutical and agrochemical applications.

Chemical Synthesis Intermediate
This compound functions as a key building block in organic synthesis, enabling the construction of diverse molecular architectures. Its reactive chlorine atom and trifluoromethyl group offer versatile points for further chemical modification.
Research and Development
Utilised in laboratories for exploring new chemical pathways and synthesising novel compounds with potential biological activity. It is a component in the early stages of drug discovery and agrochemical research.
Heterocyclic Chemistry
Serves as a precursor in the synthesis of substituted pyrimidines, a class of heterocycles important in medicinal chemistry and materials science.
| Molecular weight | 182.53 |
|---|---|
| Empirical formula | C5H2ClF3N2 |
| Assay | 99% |
| Boiling point | 60 °C/10 mmHg(lit.) |
| Density | 1.513 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.447(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 49 °C / 120.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-4-(trifluoromethyl)pyrimidine used for?
+
2-Chloro-4-(trifluoromethyl)pyrimidine is primarily used as a chemical synthesis intermediate and building block, particularly in research and development for creating novel heterocyclic compounds.
What are the CAS number and chemical formula?
+
The CAS number is 33034-67-2, and the chemical formula is C5H2ClF3N2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this product with a minimum assay of 99%. We do not represent it as USP, BP, or EP grade.
How should 2-Chloro-4-(trifluoromethyl)pyrimidine be handled safely?
+
This compound is a flammable liquid and vapour (H226), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, faceshields, gloves, and a suitable respirator, in a well-ventilated area. Store away from heat and open flames.
Is this product exported?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals.
How can I request a sample or quote?
+
Please contact our sales team via the website or direct contact details to request a sample or a quotation for this product.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis