2-Bromo-3′-hydroxyacetophenone
2-Bromo-3′-hydroxyacetophenone (CAS: 2491-37-4) is a versatile organic building block with the molecular formula C8H7BrO2 and a molecular weight of 215.04 g/mol. This compound serves as a key reactant in the synthesis of various heterocyclic compounds and biologically active molecules. Its utility spans diverse research areas, including medicinal chemistry and organic synthesis, contributing to the development of novel therapeutic agents and complex molecular structures.
Synthesis of Pyrrole Derivatives
2-Bromo-3′-hydroxyacetophenone is employed as a precursor in the synthesis of pyrrole-3-carboxylic acids. These derivatives are valuable intermediates in pharmaceutical research.
Hantzsch Reaction Participant
This compound participates in the Hantzsch reaction, enabling the formation of N-aryl-N-thiazolyl compounds. This reaction is a fundamental method for constructing thiazole rings.
Development of Anti-inflammatory Agents
It is utilised in the synthesis of disubstituted oxadiazolylindole derivatives that exhibit anti-inflammatory and analgesic properties. Some derivatives also possess nitric oxide releasing activity.
Valosin-Containing Protein Inhibitors
The compound is a building block for anilino-aryl-thiazoles, a class of molecules found to inhibit valosin-containing proteins, which are targets in certain disease pathways.
Erythropoietin Inhibitor Synthesis
2-Bromo-3′-hydroxyacetophenone is involved in the synthetic routes towards tyrosine kinase erythropoietin inhibitors, compounds relevant to the study of erythropoiesis.
E. coli Methionine Aminopeptidase Inhibitors
It serves as a reactant in the preparation of E. coli methionine aminopeptidase inhibitors, contributing to research in antimicrobial and enzymatic studies.
| Molecular weight | 215.04 |
|---|---|
| Empirical formula | C8H7BrO2 |
| Application | Reactant involved in the synthesis of: • Pyrrole-3-carboxylic acids1• N-aryl-N-thiazolyl compounds via the Hantzsch reaction2• Disubstituted oxadiazolylindole derivatives with antiinflammatory, analgesic and nitric oxide releasing activity3• Anilino-aryl-thiazoles with inhibitory activity toward valosin-containing proteins4• Tyrosine kinase erythropoietin inhibitors5• E. coli methionine aminopeptidase inhibitors6 |
| Melting point | 70-74 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3263 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34-43 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-3′-hydroxyacetophenone used for?
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2-Bromo-3′-hydroxyacetophenone is used as a reactant in the synthesis of various compounds, including pyrrole-3-carboxylic acids, N-aryl-N-thiazolyl compounds, disubstituted oxadiazolylindole derivatives with anti-inflammatory and analgesic activity, anilino-aryl-thiazoles, tyrosine kinase erythropoietin inhibitors, and E. coli methionine aminopeptidase inhibitors.
What is the CAS number and chemical formula for 2-Bromo-3′-hydroxyacetophenone?
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The CAS number is 2491-37-4 and the chemical formula is C8H7BrO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-3′-hydroxyacetophenone as a chemical for research and development purposes. The exact grade and purity are available on the product's specification sheet; we do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should 2-Bromo-3′-hydroxyacetophenone be handled safely?
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2-Bromo-3′-hydroxyacetophenone is classified as Danger (GHS05, GHS07) with hazard statements H302 (Harmful if swallowed), H314 (Causes severe skin burns and eye damage), and H317 (May cause an allergic skin reaction). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection (e.g., N100 particulate respirator), must be used. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing. Refer to the Safety Data Sheet for detailed handling and emergency procedures.
Is 2-Bromo-3′-hydroxyacetophenone a controlled substance?
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The provided data does not indicate that 2-Bromo-3′-hydroxyacetophenone is a controlled substance.
How is 2-Bromo-3′-hydroxyacetophenone packed, shipped, and exported?
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2-Bromo-3′-hydroxyacetophenone is packed according to industry standards for chemical safety and stability. As a global supplier, Tech Serve Solutions has extensive experience in exporting fine chemicals worldwide, adhering to all relevant international shipping regulations for hazardous materials (UN 3263 8 / PGII).
How can I request a sample or quote for 2-Bromo-3′-hydroxyacetophenone?
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To request a sample or a quotation for 2-Bromo-3′-hydroxyacetophenone, please contact the Tech Serve Solutions sales department through our website or by calling our customer service line. Please specify the quantity required and your delivery location.
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