2-Bromo-3′-nitroacetophenone
2-Bromo-3′-nitroacetophenone (CAS 2227-64-7) is a chemical compound with the linear formula O₂NC₆H₄COCH₂Br and a molecular weight of 244.04 g/mol. This nitro-substituted phenacyl bromide derivative serves as a valuable building block in organic synthesis. It is particularly useful in the preparation of various heterocyclic compounds and pharmaceuticals due to the reactivity of the bromomethyl ketone moiety and the presence of the nitro group, which can be further functionalised or reduced.
- IUPAC
- 3′-Nitrophenacyl bromide
- Synonyms
- 3′-Nitrophenacyl bromide
Organic Synthesis Intermediate
Used as a key intermediate in the synthesis of more complex organic molecules. Its reactive bromomethyl group readily participates in alkylation reactions with nucleophiles.
Pharmaceutical Building Block
Serves as a precursor in the development of pharmaceutical compounds. The nitro group can be reduced to an amine, enabling further derivatisation for drug discovery programmes.
Heterocyclic Chemistry
Facilitates the construction of various heterocyclic ring systems, which are common structural motifs in many biologically active compounds.
| Molecular weight | 244.04 |
|---|---|
| Linear formula | O2NC6H4COCH2Br |
| Assay | 97% |
| Melting point | 90-96 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-3′-nitroacetophenone used for?
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2-Bromo-3′-nitroacetophenone is primarily used as a versatile building block in organic synthesis, particularly in the preparation of pharmaceuticals and heterocyclic compounds.
What is the CAS number and formula for 2-Bromo-3′-nitroacetophenone?
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The CAS number is 2227-64-7 and the linear formula is O₂NC₆H₄COCH₂Br.
What grade and purity does Tech Serve Solutions supply for 2-Bromo-3′-nitroacetophenone?
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Tech Serve Solutions supplies 2-Bromo-3′-nitroacetophenone with a purity of 97% (assay). We do not represent this product as USP, BP, EP, or any pharmacopoeia grade unless explicitly stated.
How should 2-Bromo-3′-nitroacetophenone be handled safely?
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2-Bromo-3′-nitroacetophenone is classified as a Danger hazard, causing severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including eye protection, gloves, and respiratory protection. Ensure good ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
Is 2-Bromo-3′-nitroacetophenone a controlled substance?
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Based on the provided data, there is no indication that 2-Bromo-3′-nitroacetophenone (CAS 2227-64-7) is a controlled substance.
How is 2-Bromo-3′-nitroacetophenone packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant national and international regulations. Specific packaging details depend on the quantity and destination, adhering to UN 3261, Class 8, Packing Group II transport regulations.
How can I request a sample or quote for 2-Bromo-3′-nitroacetophenone?
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To request a sample or obtain a quotation for 2-Bromo-3′-nitroacetophenone, please contact our sales department via the website or by phone, providing your contact details and the quantity required.
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