2-Bromo-3′-chloro-4′-fluoroacetophenone
2-Bromo-3′-chloro-4′-fluoroacetophenone (CAS 63529-30-6), with the molecular formula C8H5BrClFO and a molecular weight of 251.48 g/mol, is a valuable halogenated aryl ketone. It serves as a key intermediate and building block in organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals. Its unique structure, featuring bromine, chlorine, and fluorine substituents on an acetophenone core, enables diverse chemical transformations for creating complex molecular architectures.
- IUPAC
- 2-Bromo-1-(3-chloro-4-fluorophenyl)ethanone,3′-Chloro-4′-fluorophenacyl bromide
- Synonyms
- 2-Bromo-1-(3-chloro-4-fluorophenyl)ethanone3′-Chloro-4′-fluorophenacyl bromide
Pharmaceutical Intermediate
This compound is employed in the synthesis of active pharmaceutical ingredients (APIs). The strategically placed halogens allow for regioselective functionalization, facilitating the construction of complex drug candidates.
Agrochemical Synthesis
It acts as a precursor in the development of new pesticides, herbicides, and fungicides. The fluorinated aromatic ring is often a desirable feature in modern agrochemical design for enhanced efficacy and metabolic stability.
Organic Building Block
As a versatile building block, it is utilised in academic and industrial research for creating novel organic molecules. Its reactivity allows for various coupling reactions and nucleophilic substitutions.
Material Science Research
The compound may find application in the synthesis of specialised organic materials where its unique electronic and structural properties can be exploited.
| Molecular weight | 251.48 |
|---|---|
| Empirical formula | C8H5BrClFO |
| Assay | 96% |
| Storage temperature | 2-8°C |
| Melting point | 33-36 °C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-3′-chloro-4′-fluoroacetophenone used for?
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2-Bromo-3′-chloro-4′-fluoroacetophenone is primarily used as an intermediate and building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals.
What is the CAS number and molecular formula for 2-Bromo-3′-chloro-4′-fluoroacetophenone?
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The CAS number is 63529-30-6 and the molecular formula is C8H5BrClFO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-3′-chloro-4′-fluoroacetophenone with an assay of 96%. This is a research or technical grade material, and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should 2-Bromo-3′-chloro-4′-fluoroacetophenone be handled safely?
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This compound is classified as Danger, with hazards including H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95 US), eyeshields, face shields, and gloves, must be worn. Handle only in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling procedures.
How is 2-Bromo-3′-chloro-4′-fluoroacetophenone packed and shipped?
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The product is shipped under UN 2811, Class 6.1, Packing Group III regulations. Storage is recommended at 2-8°C. TSS handles all export documentation and logistics for global supply.
How can I request a quote or sample for 2-Bromo-3′-chloro-4′-fluoroacetophenone?
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To request a quote or sample, please visit the product page on the Tech Serve Solutions website and use the 'Request a Quote' or 'Request Sample' options, providing your contact details and desired quantity.
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