8-Mercaptooctanoic acid
8-Mercaptooctanoic acid (CAS: 74328-61-3), with the molecular formula C8H16O2S and a molecular weight of 176.28 g/mol, is a functional thiol compound. It is primarily utilised in materials science for the formation of hydrophilic self-assembled monolayers (SAMs). These monolayers can be further modified with various end groups or used to create protective barrier layers for subsequent material deposition.
- IUPAC
- 8-Thiooctanoic acid,MOA
- Synonyms
- 8-Thiooctanoic acidMOA

Self-Assembled Monolayer (SAM) Formation
8-Mercaptooctanoic acid is employed to create hydrophilic SAMs on surfaces. The carboxylic acid termination allows for straightforward further functionalisation to introduce complex end groups, tailoring surface properties.
Surface Passivation and Barrier Layers
This compound can form a protective monolayer, acting as a barrier to facilitate the controlled deposition of oxide layers. This is particularly relevant in microelectronics and materials science applications.
Chemical Synthesis
As an organic building block containing a thiol and a carboxylic acid group, it serves as a versatile intermediate in various organic synthesis pathways.
| Molecular weight | 176.28 |
|---|---|
| Empirical formula | C8H16O2S |
| Assay | 95% |
| Density | 1.0326 g/mL at 25 °C |
| Refractive index | n20/D 1.4808 |
| Storage temperature | −20°C |
| Application | This compound is used to produce hydrophilic SAMs. The resulting monolayers which are terminated with carboxylic acids can be further functionalized1 to introduce more complex end groups. Can also be used to form a protective barrier monolayer to allow deposition of a passivating oxide layer.2 |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 8-Mercaptooctanoic acid used for?
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8-Mercaptooctanoic acid is primarily used to create hydrophilic self-assembled monolayers (SAMs) and as a protective barrier layer for subsequent material deposition. It also serves as a versatile building block in organic synthesis.
What are the CAS number and formula for 8-Mercaptooctanoic acid?
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The CAS number is 74328-61-3 and the empirical formula (Hill notation) is C8H16O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 8-Mercaptooctanoic acid with an assay of 95%. We do not represent this product as USP, BP, or EP grade.
How should 8-Mercaptooctanoic acid be handled?
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Based on GHS information, 8-Mercaptooctanoic acid is classified as causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and suitable gloves, should be worn. Avoid inhalation of vapours and ensure adequate ventilation.
Is 8-Mercaptooctanoic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 8-Mercaptooctanoic acid.
How can I request a sample or quote for 8-Mercaptooctanoic acid?
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Please contact our sales team directly via the website or by phone to request a sample or a quotation for 8-Mercaptooctanoic acid.
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