2,6-Difluorophenylacetonitrile
2,6-Difluorophenylacetonitrile (CAS 654-01-3) is a fluorinated organic building block with the linear formula F₂C₆H₃CH₂CN and a molecular weight of 153.13 g/mol. This compound serves as a valuable intermediate in chemical synthesis, particularly for creating complex organic molecules. Its structure, featuring a difluorinated phenyl ring and a nitrile group, makes it useful in the development of pharmaceuticals and agrochemicals. TSS offers this chemical with an assay of 96%.
- Synonyms
- 2,6-Difluorobenzyl cyanideF2C6H3CH2CN
Synthesis of Substituted Butyrates
2,6-Difluorophenylacetonitrile is utilised as a key reactant in the synthesis of compounds such as ethyl 4-(2,6-difluorophenyl)-2-ethyl-3-oxobutyrate. This application highlights its role in constructing complex carbon frameworks for further chemical elaboration.
Fluorinated Aromatic Intermediate
As a difluorinated aromatic nitrile, this compound is an important building block for introducing fluorinated phenyl moieties into larger molecules. This is crucial in medicinal chemistry and materials science where fluorine substitution can significantly alter a compound's properties.
Research and Development
2,6-Difluorophenylacetonitrile is employed in academic and industrial research laboratories for exploring novel synthetic routes and developing new chemical entities. Its reactive nitrile group and substituted aromatic ring offer versatility in various organic transformations.
| Molecular weight | 153.13 |
|---|---|
| Linear formula | F2C6H3CH2CN |
| Assay | 96% |
| Density | 1.238 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.481(lit.) |
| Application | 2,6-Difluorophenylacetonitrile has been used in the synthesis of ethyl 4-(2,6-difluorophenyl)-2-ethyl-3-oxobutyrate1. |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 53 °C / 127.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38 |
| Safety statements (S) | 16-26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorophenylacetonitrile used for?
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2,6-Difluorophenylacetonitrile is primarily used as an intermediate in organic synthesis, particularly for the preparation of fluorinated compounds like substituted butyrates, and in research and development for creating new chemical entities.
What are the CAS number and formula for 2,6-Difluorophenylacetonitrile?
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The CAS number for 2,6-Difluorophenylacetonitrile is 654-01-3, and its linear formula is F₂C₆H₃CH₂CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluorophenylacetonitrile with a purity of 96% (assay). This product is not represented as USP, BP, or EP grade.
How should 2,6-Difluorophenylacetonitrile be handled safely?
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2,6-Difluorophenylacetonitrile is a flammable liquid and vapour (H226) and is harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332). It also causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, should be used. Handle in a well-ventilated area away from ignition sources.
How is 2,6-Difluorophenylacetonitrile packaged and exported?
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2,6-Difluorophenylacetonitrile is carefully packaged to ensure safe transit and is available for global export by Tech Serve Solutions, adhering to all relevant shipping regulations for hazardous materials (UN 1993).
How can I request a quote or sample for 2,6-Difluorophenylacetonitrile?
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To request a quote or a sample of 2,6-Difluorophenylacetonitrile, please contact the Tech Serve Solutions sales team via our website or by phone, providing your specific requirements.
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