2,6-Difluorophenylboronic acid
2,6-Difluorophenylboronic acid (CAS 162101-25-9), with the linear formula F₂C₆H₃B(OH)₂, is an aryl boronic acid derivative crucial for chemical synthesis. This organometallic reagent, boasting a molecular weight of 157.91 g/mol, serves as a valuable building block in organic chemistry, particularly in cross-coupling reactions. Its precise structure and reactivity make it a sought-after intermediate for developing complex organic molecules.
- Synonyms
- F2C6H3B(OH)2
Suzuki-Miyaura Coupling Reagent
2,6-Difluorophenylboronic acid is extensively employed as a coupling partner in Suzuki-Miyaura reactions. This facilitates the formation of new carbon-carbon bonds, enabling the synthesis of biaryl compounds with specific difluorophenyl substitution patterns.
Organic Synthesis Intermediate
This compound acts as a versatile intermediate in multi-step organic synthesis. It can be readily functionalised, allowing for the introduction of the 2,6-difluorophenyl moiety into diverse molecular architectures.
Medicinal Chemistry Building Block
The 2,6-difluorophenyl group is a common structural motif in pharmaceuticals. 2,6-Difluorophenylboronic acid provides a convenient route for incorporating this pharmacologically relevant fragment during drug discovery and development.
Materials Science Applications
In materials science, aryl boronic acids like this compound can be used in the synthesis of advanced organic materials, such as conjugated polymers or optoelectronic devices, where specific electronic or structural properties are desired.
| Molecular weight | 157.91 |
|---|---|
| Linear formula | F2C6H3B(OH)2 |
| Assay | 98% |
| Melting point | 147-149 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorophenylboronic acid used for?
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2,6-Difluorophenylboronic acid is primarily used as a reagent in Suzuki-Miyaura coupling reactions, as an intermediate in organic synthesis, and as a building block in medicinal chemistry and materials science.
What are the CAS number and formula for 2,6-Difluorophenylboronic acid?
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The CAS number is 162101-25-9, and the linear formula is F₂C₆H₃B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluorophenylboronic acid with an assay of 98%. We do not represent this product as USP, EP, BP, or any other pharmacopoeia grade.
How should 2,6-Difluorophenylboronic acid be handled safely?
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Handle with care. It is a Warning substance (GHS07) causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Wear appropriate PPE, including eyeshields, gloves, and a dust mask (type N95 or equivalent). Ensure good ventilation.
How is 2,6-Difluorophenylboronic acid packed and shipped?
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Tech Serve Solutions exports fine chemicals globally, ensuring secure and compliant packaging suitable for international transport.
How can I request a quote or sample for 2,6-Difluorophenylboronic acid?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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