1-(Trifluoromethyl)acetylbenzotriazole
1-(Trifluoromethyl)acetylbenzotriazole (CAS: 183266-61-7; Formula: C8H4F3N3O; MW: 215.13) is a versatile organic compound supplied by Tech Serve Solutions. It serves as a key reactant in various synthetic procedures, notably in C-C bond formation and trifluoroacetylation reactions. Its utility extends to the preparation of biologically relevant scaffolds, including those with potential anticancer activity, and the synthesis of dipeptide mimetics, making it a valuable reagent in medicinal chemistry and advanced organic synthesis.
- IUPAC
- 1-Benzotriazol-1-yl-2,2,2-trifluoroethanone,N-Trifluoroacetylbenzotriazole,TFABI
Trifluoroacetylation Agent
This compound functions as an effective trifluoroacetylating agent, introducing the trifluoroacetyl group in organic synthesis. This is crucial for modifying molecules and preparing diverse chemical entities.
C-C Bond Formation
It participates in C-C bond formation reactions, including defluorination dimerization reactions mediated by single electron transfer reagents. This capability is fundamental in constructing complex molecular architectures.
Preparation of Anticancer Scaffolds
The compound is employed in the synthesis of molecular scaffolds possessing anticancer activity, specifically against breast cancer cells. This highlights its importance in the development of novel chemotherapeutic agents.
Synthesis of Peptide Mimetics
It is utilised in the synthesis of aspartylglycine dipeptide mimetics, contributing to the creation of stable and functional analogues of natural peptides for research and pharmaceutical applications.
Coupling Reactions
1-(Trifluoromethyl)acetylbenzotriazole is used in coupling reactions for the synthesis of carboxylic acid esters, enabling efficient esterification pathways in organic synthesis.
| Molecular weight | 215.13 |
|---|---|
| Empirical formula | C8H4F3N3O |
| Assay | 96% |
| Application | Reactant for:• Defluorination dimerization reactions mediated by single electron transfer (SET) reagent, sodium naphthalenide1• Preparation of scaffolds endowed with anticancer activity against breast cancer cells2• Synthesis of aspartylglycine dipeptide mimetic3• Coupling reactions for synthesis of carboxylic acid esters4• Trifluoroacetylation reactions (Trifluoroacetylating agent)5 |
| Composition | mixture of Bt1 and Bt2 isomers |
| Melting point | 66-70 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(Trifluoromethyl)acetylbenzotriazole used for?
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1-(Trifluoromethyl)acetylbenzotriazole is used as a reactant in defluorination dimerization reactions, for the preparation of scaffolds with anticancer activity, in the synthesis of aspartylglycine dipeptide mimetics, in coupling reactions for carboxylic acid ester synthesis, and as a trifluoroacetylating agent.
What is the CAS number and chemical formula for 1-(Trifluoromethyl)acetylbenzotriazole?
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The CAS number is 183266-61-7 and the chemical formula is C8H4F3N3O.
What grade and purity does Tech Serve Solutions supply for 1-(Trifluoromethyl)acetylbenzotriazole?
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Tech Serve Solutions supplies 1-(Trifluoromethyl)acetylbenzotriazole with a minimum assay of 96%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, or EP grade.
How should 1-(Trifluoromethyl)acetylbenzotriazole be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Consult the Safety Data Sheet for comprehensive safety information.
How is 1-(Trifluoromethyl)acetylbenzotriazole packed and shipped?
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Products are carefully packed according to international shipping regulations and are available for global export by Tech Serve Solutions.
How can I request a quote or sample for 1-(Trifluoromethyl)acetylbenzotriazole?
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To request a quote or sample, please use the contact form on our website or contact our sales team directly.
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