1-(Trifluoroacetyl)imidazole
1-(Trifluoroacetyl)imidazole (CAS: 1546-79-8; Formula: C5H3F3N2O; MW: 164.09) is a valuable chemical intermediate and acylation reagent. It is primarily used for the derivatization of various compounds, particularly for gas chromatography (GC) analysis. Its reactive nature makes it suitable for introducing trifluoroacetyl groups into molecules, enhancing their detectability and separation characteristics.
Gas Chromatography Derivatization
1-(Trifluoroacetyl)imidazole serves as an effective derivatization reagent for GC analysis. It reacts with analytes containing active hydrogens, such as amines and phenols, to form volatile trifluoroacetyl derivatives, improving chromatographic separation and detection sensitivity.
Acylation Reactions
This compound is employed as an acylating agent in organic synthesis. It can introduce the trifluoroacetyl moiety into various nucleophiles, facilitating the synthesis of fluorinated organic compounds and intermediates.
Analytical Reagent
Its ability to react selectively makes it a useful reagent in analytical chemistry for the preparation of specific derivatives for identification and quantification purposes.
| Molecular weight | 164.09 |
|---|---|
| Empirical formula | C5H3F3N2O |
| Assay | 98% |
| Grade | for GC derivatization |
| Boiling point | 137 °C(lit.)45-46 °C/14 mmHg(lit.) |
| Density | 1.442 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.424(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 44 °C / 111.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(Trifluoroacetyl)imidazole used for?
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1-(Trifluoroacetyl)imidazole is primarily used as a derivatization reagent for gas chromatography (GC) and as an acylating agent in organic synthesis to introduce trifluoroacetyl groups.
What is the CAS number and formula for 1-(Trifluoroacetyl)imidazole?
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The CAS number is 1546-79-8 and the empirical formula is C5H3F3N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(Trifluoroacetyl)imidazole with an assay of 98% and a grade specified for GC derivatization. We do not represent this product as USP, BP, or EP grade.
How should 1-(Trifluoroacetyl)imidazole be handled?
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1-(Trifluoroacetyl)imidazole is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including safety glasses, face shields, and gloves, in a well-ventilated area.
Is 1-(Trifluoroacetyl)imidazole a controlled substance?
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The provided data does not indicate that 1-(Trifluoroacetyl)imidazole is a controlled substance.
How is 1-(Trifluoroacetyl)imidazole packed and shipped?
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1-(Trifluoroacetyl)imidazole is shipped as a UN 1993, Class 3, Packing Group III hazardous material. Specific packaging details are available upon request.
How can I request a sample or quote for 1-(Trifluoroacetyl)imidazole?
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To request a sample or quote, please contact our sales team through the website or by phone, providing your specific requirements.
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