1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester
1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester (CAS: 864754-19-8), with the molecular formula C14H19BN2O2S, is a valuable organoboron compound. It serves as a key building block in organic synthesis, particularly for constructing complex heterocyclic molecules. Its structure, featuring a pyrazole ring functionalized with a thiophene moiety and a boronate ester group, makes it ideal for cross-coupling reactions, enabling the formation of carbon-carbon and carbon-heteroatom bonds.
- IUPAC
- 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-thienylmethyl)-1H-pyrazole
- Synonyms
- 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-thienylmethyl)-1H-pyrazole
Suzuki-Miyaura Cross-Coupling Reactions
This boronate ester is widely employed as a coupling partner in Suzuki-Miyaura reactions. It facilitates the efficient formation of C-C bonds with aryl and heteroaryl halides, leading to diverse biaryl and heteroaryl-pyrazole structures.
Synthesis of Pharmaceutical Intermediates
The compound is utilized in the synthesis of advanced intermediates for the pharmaceutical industry. Its versatile reactivity allows for the introduction of specific pyrazole and thiophene motifs into potential drug candidates.
Materials Science Research
It can be incorporated into the design and synthesis of novel organic materials. The unique electronic properties conferred by the thiophene and pyrazole rings may be beneficial for applications in organic electronics.
Agrochemical Development
This boronate ester can serve as a scaffold or intermediate in the development of new agrochemicals, where heterocyclic structures are often explored for biological activity.
| Molecular weight | 290.19 |
|---|---|
| Empirical formula | C14H19BN2O2S |
| Assay | 97% |
| Melting point | 56-58 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester used for?
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This compound is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, and in the development of pharmaceutical intermediates, materials science research, and agrochemicals.
What are the CAS number and molecular formula for this product?
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The CAS number is 864754-19-8, and the molecular formula is C14H19BN2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a minimum purity of 97%. It is typically considered a research or technical grade material and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK rating of 2 in Germany, indicating it is hazardous to water.
Is this product suitable for export and shipment?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including this product. We adhere to all relevant shipping and customs regulations.
How can I request a sample or quote?
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Please contact our sales department through the website or by phone to request a sample or a detailed quotation for 1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester.
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