1-(3-Hydroxyphenyl) piperazine
1-(3-Hydroxyphenyl) piperazine (CAS 59817-32-2; C10H14N2O; molar mass 178.23 g/mol) is a heterocyclic building block in which a piperazine ring is N-substituted with a 3-hydroxyphenyl group. Also known as 3-(1-piperazino)phenol, it is a crystalline solid (m.p. 217-221 degC) supplied at 97% assay. Tech Serve Solutions offers it as a research-grade intermediate for chemical synthesis and medicinal-chemistry programmes worldwide.
- IUPAC
- 3-(1-Piperazino)phenol
- Synonyms
- 1-(3-Hydroxyphenyl)piperazine3-(1-Piperazino)phenol3-(Piperazin-1-yl)phenol1-(3-Hydroxyphenyl)piperazine free base
Pharmaceutical and medicinal-chemistry intermediate
Serves as a building block for piperazine-based drug candidates and structure-activity studies. The free phenol and secondary amine offer two distinct, selectively addressable sites for further derivatisation.
Heterocyclic building block
Used in chemical synthesis to install a 3-hydroxyphenyl-piperazine motif onto larger scaffolds. It is a versatile reagent for N-alkylation, N-acylation, sulfonylation and reductive amination.
Phenol-directed functionalisation
The aromatic hydroxyl group supports O-alkylation, etherification, acylation and coupling chemistry, enabling access to aryl ethers, esters and related derivatives.
Research and laboratory reagent
Supplied as a defined-purity reagent for exploratory synthesis, reference-compound preparation and process-development work in research settings.
| Molecular weight | 178.23 |
|---|---|
| Empirical formula | C10H14N2O |
| Assay | 97% |
| Melting point | 217-221 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Hydroxyphenyl) piperazine used for?
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It is used mainly as a heterocyclic building block and intermediate in chemical synthesis and medicinal chemistry. Its piperazine nitrogen and aromatic hydroxyl group provide two reactive handles for constructing more complex molecules, including piperazine-based drug candidates.
What is the CAS number and molecular formula of 1-(3-Hydroxyphenyl) piperazine?
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The CAS number is 59817-32-2 and the molecular formula is C10H14N2O, with a molecular weight of 178.23 g/mol. The MDL number is MFCD00052896 and it is also known as 3-(1-piperazino)phenol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(3-Hydroxyphenyl) piperazine at a typical assay of 97% as a research/technical-grade intermediate. We do not represent it as a USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch.
What are the safety and handling requirements for 1-(3-Hydroxyphenyl) piperazine?
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It is classified under GHS05 and GHS06 with the signal word Danger. The hazard statements are H301 (toxic if swallowed), H315 (causes skin irritation), H318 (causes serious eye damage) and H335 (may cause respiratory irritation). Handle with gloves, eye and face protection and an N95-type dust mask, avoid dust formation, and consult the SDS before use. It carries a high water-hazard rating (WGK 3).
How is 1-(3-Hydroxyphenyl) piperazine packed, shipped and exported?
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It is packed in sealed, labelled containers appropriate to the order quantity, from laboratory packs to bulk. For transport it is classified as UN 2811, Class 6.1, Packing Group III (toxic solid), and is shipped in compliance with applicable dangerous-goods regulations. We export worldwide with full documentation and a certificate of analysis.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity specification and destination, and our team will respond with availability, lead time and documentation. Samples can be arranged subject to stock and regulatory requirements.
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