1-(3-Fluorophenyl)vinylboronic acid pinacol ester
1-(3-Fluorophenyl)vinylboronic acid pinacol ester (CAS 1239700-55-0; C14H18BFO2; molar mass 248.10 g/mol) is an aryl-substituted vinyl boronate ester, also named 2-[1-(3-fluorophenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. Supplied as a liquid of approximately 97% assay, it is a pinacol boronate building block used chiefly as a coupling partner in Suzuki-Miyaura cross-coupling to install a 1-(3-fluorophenyl)vinyl group. Tech Serve Solutions supplies it as a research-grade reagent for organic synthesis.
- IUPAC
- 2-[1-(3-Fluorophenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Synonyms
- 1-(3-Fluorophenyl)vinylboronic acid pinacol ester2-[1-(3-Fluorophenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane1-(3-Fluorophenyl)ethenylboronic acid pinacol ester3-Fluorophenyl vinyl pinacol boronateCAS 1239700-55-0
Suzuki-Miyaura cross-coupling
Acts as the organoboron partner in palladium-catalysed Suzuki-Miyaura reactions with aryl or heteroaryl halides and pseudohalides. The stabilised pinacol ester allows controlled carbon-carbon bond formation under standard coupling conditions.
Vinyl/styrenyl group installation
Introduces a substituted 1-(3-fluorophenyl)vinyl unit onto a target scaffold, providing access to fluorinated styrene-type intermediates and extended conjugated systems.
Pharmaceutical and agrochemical intermediates
Serves as a boronate building block in medicinal-chemistry and agrochemical discovery programmes where a fluorinated aromatic vinyl motif is required. Specific applications depend on the target route.
Fluorinated building block
The meta-fluorine on the aryl ring is a common motif for modulating electronic properties, metabolic stability and binding in structure-activity studies, making this reagent useful for fluorine-containing analogues.
Research and method development
Used at laboratory scale to develop and screen cross-coupling methodologies, catalyst systems and reaction conditions involving vinyl pinacol boronates.
| Molecular weight | 248.10 |
|---|---|
| Empirical formula | C14H18BFO2 |
| Assay | 97% |
| Density | 1.041 g/mL at 25 °C |
| Refractive index | n20/D 1.499 |
| Storage temperature | 2-8°C |
| Flash point | >100 °C / >212 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Fluorophenyl)vinylboronic acid pinacol ester used for?
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It is used mainly as an organoboron reagent in Suzuki-Miyaura cross-coupling, where it transfers a 1-(3-fluorophenyl)vinyl group to aryl and heteroaryl partners. As a fluorinated vinyl boronate building block, it supports the synthesis of pharmaceutical, agrochemical and fine-chemical intermediates and the development of cross-coupling methods.
What is the CAS number and molecular formula of 1-(3-Fluorophenyl)vinylboronic acid pinacol ester?
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Its CAS number is 1239700-55-0 and its molecular formula is C14H18BFO2, with a molecular weight of 248.10 g/mol. It is also known systematically as 2-[1-(3-fluorophenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (MDL number MFCD18383357).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research-grade reagent with a typical assay of approximately 97%. It is supplied as a liquid (refractive index n20/D 1.499; density 1.041 g/mL at 25 C). We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each batch.
How should 1-(3-Fluorophenyl)vinylboronic acid pinacol ester be stored and handled?
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Store refrigerated at 2-8 C in a tightly closed container, away from moisture and ignition sources; it has a flash point above 100 C. It is classified WGK 3 (German Water Hazard Class 3), indicating a severe hazard to water, so prevent release to drains and watercourses. Handle as a research chemical with gloves, eye protection and good ventilation, and consult the current Safety Data Sheet before use.
How is 1-(3-Fluorophenyl)vinylboronic acid pinacol ester packed, shipped and exported?
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It is packed in suitable sealed containers sized from gram quantities to bulk research volumes, with tamper-evident, moisture-resistant packaging and full labelling. Tech Serve Solutions ships domestically and exports worldwide under temperature-controlled, compliant conditions, with a certificate of analysis and Safety Data Sheet included with each consignment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, quoting CAS 1239700-55-0 and product 10388. We will confirm availability, lead time, documentation and export terms, and can arrange a sample for evaluation where appropriate.
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