1-(3-Fluorobenzyl)piperazine
1-(3-Fluorobenzyl)piperazine (CAS 55513-19-4) is a fluorinated piperazine building block with the molecular formula C11H15FN2 and a molecular weight of 194.25 g/mol. It pairs a secondary piperazine ring with a 3-fluorobenzyl group, making it a versatile heterocyclic intermediate for chemical synthesis and medicinal-chemistry research. Tech Serve Solutions supplies it at 97% assay as a research-grade reagent for laboratory and process development use worldwide.
- Synonyms
- 1-(3-Fluorobenzyl)piperazine1-(3-fluorobenzyl)piperazine3-fluorobenzylpiperazine1-[(3-fluorophenyl)methyl]piperazineCAS 55513-19-4
Pharmaceutical and medicinal-chemistry intermediate
The mono-substituted piperazine offers a free secondary nitrogen for acylation, alkylation and sulfonylation, making it a convenient scaffold for building drug-discovery libraries and active-ingredient intermediates.
Fluorinated building block
The meta-fluorobenzyl group introduces a stable C-F bond that is widely used to modulate the metabolic stability, lipophilicity and binding properties of target molecules during structure-activity studies.
Heterocyclic synthesis
As a piperazine derivative it serves as a nucleophilic partner in N-functionalisation, reductive amination and cross-coupling routes to more complex nitrogen heterocycles.
Research and laboratory reagent
Supplied at 97% assay, it is suited to bench-scale exploratory chemistry, reference-standard preparation and method-development work.
| Molecular weight | 194.25 |
|---|---|
| Empirical formula | C11H15FN2 |
| Assay | 97% |
| Boiling point | 281.3 °C/760 mmHg |
| Density | 1.106 g/mL at 25 °C |
| Refractive index | n20/D 1.529 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Fluorobenzyl)piperazine used for?
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It is primarily used as a fluorinated heterocyclic building block in chemical synthesis and medicinal-chemistry research. The free piperazine nitrogen is readily functionalised, so the compound is commonly employed as an intermediate in the preparation of pharmaceutical candidates and other nitrogen-containing target molecules.
What is the CAS number and molecular formula of 1-(3-Fluorobenzyl)piperazine?
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The CAS number is 55513-19-4 and the molecular formula is C11H15FN2 (Hill notation), giving a molecular weight of 194.25 g/mol. The MDL number is MFCD02242870.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(3-Fluorobenzyl)piperazine at a typical assay of 97% as a research/technical-grade reagent. We do not represent this material as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and specific assay or documentation requirements can be confirmed on enquiry.
What are the key physical properties of 1-(3-Fluorobenzyl)piperazine?
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Reported properties include a boiling point of approximately 281.3 °C at 760 mmHg, a density of 1.106 g/mL at 25 °C, a refractive index of n20/D 1.529 and a flash point above 110 °C (>230 °F).
How should 1-(3-Fluorobenzyl)piperazine be handled and stored safely?
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Handle only with suitable personal protective equipment, including eye shields, gloves and appropriate respiratory protection, and work under adequate ventilation. The material is classified WGK 3 (severely hazardous to water in Germany), so prevent release to drains and the environment. Always consult the current Safety Data Sheet for the full GHS classification and handling guidance before use.
How is 1-(3-Fluorobenzyl)piperazine packed, shipped and exported?
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The product is packed in appropriately sealed, labelled containers sized to the order, from gram quantities to larger research volumes, with packaging selected to protect the material in transit. As a global exporter, Tech Serve Solutions arranges export documentation and compliant international shipping in line with applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity and any specification or documentation needs, and our team will respond with availability, lead time and a quotation. Sample requests for evaluation can be accommodated on enquiry.
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