1-(3-Chlorophenyl)piperazine hydrochloride
1-(3-Chlorophenyl)piperazine hydrochloride (CAS 65369-76-8; free base C10H13ClN2, molar mass 196.68 g/mol), widely known as m-CPP, is a halogenated arylpiperazine supplied as a crystalline solid that is soluble in methanol and melts at about 210-214 °C with decomposition. A well-characterised serotonergic research biochemical and heterocyclic building block, it is used chiefly as an analytical reference standard and in neuroscience and medicinal-chemistry studies. Tech Serve Solutions supplies it at 99% assay for research use.
- IUPAC
- m-CPP
- Synonyms
- 1-(3-Chlorophenyl)piperazine hydrochloridem-CPPmCPPCPP3-chlorophenylpiperazine hydrochloride1-(3-chlorophenyl)piperazine HClmeta-chlorophenylpiperazine hydrochlorideCAS 65369-76-8EC 265-718-0MFCD00039032
Analytical reference standard
Used as a characterised reference material for the determination of designer piperazines in biological specimens such as urine by GC-MS and LC-ESI-MS. It supports method development, calibration and confirmatory testing in forensic and toxicology laboratories.
Neuroscience research reagent
m-CPP is a well-documented serotonin-receptor-active arylpiperazine applied in cell-signalling and neurotransmission studies. It is used as a pharmacological tool compound to probe serotonergic pathways in vitro.
Heterocyclic building block
Serves as a halogenated piperazine building block in medicinal-chemistry and fine-chemical synthesis, where the 3-chlorophenylpiperazine motif is a common pharmacophore for library and analogue preparation.
Reference and characterisation work
Applied as a laboratory reference reagent in analytical method validation, structure-activity studies and the characterisation of related arylpiperazine compounds.
| Molecular weight | 196.68 (free base basis) |
|---|---|
| Empirical formula | C10H13ClN2 · xHCl |
| Assay | 99% |
| Solubility | methanol: soluble |
| Application | 1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS1. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi 2. |
| Melting point | 210-214 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Htr1a(24473) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Chlorophenyl)piperazine hydrochloride used for?
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It is used mainly as an analytical reference standard and a neuroscience research reagent. As m-CPP, it serves as a reference material for detecting designer piperazines in urine by GC-MS and LC-ESI-MS, as a serotonergic tool compound in neurotransmission studies, and as a halogenated piperazine building block in medicinal-chemistry synthesis. It is supplied for research and laboratory use only.
What is the CAS number and molecular formula of 1-(3-Chlorophenyl)piperazine hydrochloride?
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Its CAS number is 65369-76-8 and the empirical formula is C10H13ClN2 · xHCl, with a free-base molecular weight of 196.68 g/mol. Related identifiers include EC number 265-718-0, MDL number MFCD00039032 and PubChem Substance ID 24847652.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a minimum assay of 99% as a research-grade reference reagent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and full specifications are confirmed at the time of quotation.
What are the safety and handling precautions?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation and use adequate ventilation (P261, P305+P351+P338). It carries German Water Hazard Class WGK 3, so prevent release into drains and watercourses. Always consult the SDS before use.
Is 1-(3-Chlorophenyl)piperazine hydrochloride a controlled substance?
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The supplied data does not indicate international scheduling under the UN drug conventions, and Tech Serve Solutions supplies it strictly as a reference and research reagent. However, m-CPP is regulated in some jurisdictions, so buyers are responsible for confirming the import, possession and use requirements that apply in their own country before ordering.
How is 1-(3-Chlorophenyl)piperazine hydrochloride packed, shipped and exported?
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It is packed as a solid in tightly closed, suitably lined containers sized from gram research quantities to larger lots, with labelling and documentation prepared to applicable transport and export requirements. Tech Serve Solutions exports worldwide and provides the SDS and certificate of analysis with each shipment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, assay and packaging, and we will confirm availability, specification and lead time. Samples can be arranged for evaluation and qualification ahead of larger orders, subject to applicable regulatory checks.
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