1-(3-Chloropropionyl)-1H-benzotriazole
1-(3-Chloropropionyl)-1H-benzotriazole (CAS 304660-39-7; C9H8ClN3O; molar mass 209.63 g/mol) is a benzotriazole-activated acyl reagent supplied at 97% assay as a low-melting crystalline solid (m.p. 76-80 °C). As a stable, easily handled N-acylbenzotriazole, it transfers a 3-chloropropionyl group to amines, alcohols and other nucleophiles, and serves as a heterocyclic building block for C-C bond formation and chemical synthesis. Tech Serve Solutions supplies and exports it for research and manufacturing use.
- IUPAC
- 1-(2-Chloroethylcarbonyl)-1H-benzotriazole
- Synonyms
- 1-(3-Chloropropionyl)-1H-benzotriazole1-(2-Chloroethylcarbonyl)-1H-benzotriazole3-Chloro-1-(1H-benzotriazol-1-yl)propan-1-one1-(3-chloropropanoyl)benzotriazoleN-(3-chloropropionyl)benzotriazole
N-acylation and amide formation
Acts as a bench-stable acyl-transfer reagent that delivers the 3-chloropropionyl moiety to amines under mild conditions, providing a convenient alternative to the corresponding acid chloride for preparing amides.
O-acylation of alcohols
Used to esterify alcohols and related hydroxyl-bearing substrates, where the benzotriazole leaving group enables controlled acylation with the benzotriazole released as a readily removed by-product.
Heterocyclic building block
Functions as a halogenated benzotriazole building block in multi-step synthesis. The pendant chloroethyl chain offers a reactive handle for further substitution, cyclisation or chain extension.
C-C bond-forming reagent
N-acylbenzotriazoles of this type are employed as activated acyl donors in carbon-carbon bond-forming reactions, supporting the construction of ketone and related frameworks in synthetic chemistry.
Research and process development
Supplied as a synthetic reagent for laboratory research, route scouting and process development across pharmaceutical-intermediate and fine-chemical programmes.
| Molecular weight | 209.63 |
|---|---|
| Empirical formula | C9H8ClN3O |
| Assay | 97% |
| Melting point | 76-80 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Chloropropionyl)-1H-benzotriazole used for?
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It is used as a stable, easily handled N-acylbenzotriazole acylating reagent that transfers a 3-chloropropionyl group to amines, alcohols and other nucleophiles. It also serves as a halogenated benzotriazole building block for C-C bond formation and multi-step chemical synthesis.
What is the CAS number and molecular formula of 1-(3-Chloropropionyl)-1H-benzotriazole?
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Its CAS number is 304660-39-7 and its molecular formula is C9H8ClN3O, with a molecular weight of 209.63 g/mol and MDL number MFCD01213671. It is a crystalline solid with a melting point of 76-80 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(3-Chloropropionyl)-1H-benzotriazole at a typical assay of 97% as a synthetic reagent for research and manufacturing use. It is offered as a technical/research grade; we do not represent it as USP, BP or EP pharmacopoeial grade.
What are the safety and handling requirements?
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It carries GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow the precautionary advice P261 and P305+P351+P338. Always consult the Safety Data Sheet before use.
Is it a controlled or scheduled substance?
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The supplied data does not indicate any drug-control or scheduling status for this compound. It is classified for water-hazard purposes as WGK Germany 3 (highly hazardous to water), so prevent release to the environment and dispose of in accordance with local regulations.
How is 1-(3-Chloropropionyl)-1H-benzotriazole packed, shipped and exported?
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It is supplied in tightly closed, suitably labelled containers sized to the order, with full documentation including a Certificate of Analysis and Safety Data Sheet. As a specialist exporter, Tech Serve Solutions arranges compliant international shipment in line with applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, intended grade and destination, and our team will confirm availability, lead time and documentation. We can provide samples and quotations for both research-scale and bulk requirements.
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