1-(3-Chloropropyl)piperidine monohydrochloride
1-(3-Chloropropyl)piperidine monohydrochloride (CAS 5472-49-1; C8H16ClN·HCl; molar mass 198.13 g/mol) is a crystalline heterocyclic building block supplied at 97% assay. It is the hydrochloride salt of a piperidine bearing a reactive 3-chloropropyl side chain, combining a secondary alkyl chloride with a tertiary amine. This bifunctional reagent is used chiefly in chemical synthesis to install the 3-(piperidin-1-yl)propyl group, serving research and intermediate manufacture for pharmaceutical and fine-chemical applications.
- Synonyms
- 1-(3-Chloropropyl)piperidine monohydrochloride1-(3-Chloropropyl)piperidine hydrochloride3-(1-Piperidinyl)propyl chloride hydrochloride1-(3-Chloropropyl)piperidinium chlorideN-(3-Chloropropyl)piperidine hydrochlorideCAS 5472-49-1
Piperidine alkylating building block
The reactive 3-chloropropyl chain acts as a handle for N- and O-alkylation, allowing the 3-(piperidin-1-yl)propyl moiety to be appended to amines, phenols and other nucleophiles. This makes it a convenient three-carbon spacer in chemical synthesis.
Pharmaceutical intermediate
As a piperidine-containing fragment, it is employed in the synthesis of active pharmaceutical ingredients and candidate molecules where a basic aminopropyl tether to a piperidine ring is required. We supply it for research and intermediate use only.
Heterocyclic and halogenated chemistry
Classified among halogenated heterocyclic building blocks, it provides both a saturated nitrogen heterocycle and a displaceable chloride, supporting nucleophilic substitution, cyclisation and side-chain elaboration routes.
Laboratory reagent and reference material
The defined 97% assay and stable hydrochloride salt form make it suitable as a reagent and characterisation reference in method development and process research.
| Molecular weight | 198.13 |
|---|---|
| Empirical formula | C8H16ClN · HCl |
| Assay | 97% |
| Melting point | 219-223 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Chloropropyl)piperidine monohydrochloride used for?
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It is used mainly as a building block in chemical synthesis to introduce the 3-(piperidin-1-yl)propyl group via alkylation of amines, phenols and related nucleophiles. The reactive chloropropyl chain and piperidine ring make it useful in pharmaceutical-intermediate and fine-chemical research.
What is the CAS number and molecular formula of 1-(3-Chloropropyl)piperidine monohydrochloride?
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Its CAS number is 5472-49-1 and its empirical formula is C8H16ClN·HCl (the hydrochloride salt), with a molecular weight of 198.13 g/mol. The MDL number is MFCD00012838 and the EC number is 226-812-7.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(3-Chloropropyl)piperidine monohydrochloride at a typical assay of 97% as a research and laboratory reagent grade. We do not represent it as USP, BP or EP pharmacopoeial grade; a certificate of analysis is provided with each lot, and a literature melting point of 219-223 °C is reported.
What are the safety and handling requirements?
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It carries GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow precautionary statements P261 and P305+P351+P338. It is assigned Water Hazard Class WGK 3 (Germany), so avoid release to the environment.
Is 1-(3-Chloropropyl)piperidine monohydrochloride a controlled or scheduled substance?
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The supplied data indicates no drug-control or scheduling status for this material. Customers remain responsible for confirming the regulatory status applicable in their own jurisdiction prior to import or use.
How is 1-(3-Chloropropyl)piperidine monohydrochloride packed, shipped and exported?
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It is packed as a solid in tightly closed, appropriately labelled containers sized to the order, from laboratory quantities to bulk. Tech Serve Solutions exports worldwide with full documentation, including a certificate of analysis and safety data sheet, observing applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination to receive a quotation, current availability and a sample where applicable. Quote the CAS number 5472-49-1 to ensure accurate identification.
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