1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride (CAS 52605-52-4; C13H18Cl2N2 · HCl; molar mass 309.66 g/mol) is a halogenated piperazine building block supplied as a crystalline solid melting at about 198-203 °C. It pairs a 3-chlorophenylpiperazine core with a reactive 3-chloropropyl chain, making it a versatile alkylating intermediate for pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it at 97% assay for research and manufacturing use.
- Synonyms
- 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloridem-chlorophenylpiperazine chloropropyl derivative hydrochlorideCAS 52605-52-4EC 258-038-0MFCD00067039
Pharmaceutical intermediate
Serves as a piperazine side-chain precursor in the synthesis of active pharmaceutical ingredients and their analogues. It is widely documented as an intermediate associated with the preparation of trazodone-type structures.
Heterocyclic building block
Used as a halogenated heterocyclic building block in medicinal-chemistry programmes and library synthesis, where the 3-chlorophenylpiperazine motif is a common pharmacophore.
Alkylation and N-functionalisation
The terminal 3-chloropropyl group acts as a reactive handle for nucleophilic substitution, allowing the piperazine unit to be coupled to amines, alcohols, phenols and other nucleophiles.
Reference and research reagent
Applied as a characterised reference material and laboratory reagent in process development, route scouting and analytical method work.
| Molecular weight | 309.66 |
|---|---|
| Empirical formula | C13H18Cl2N2 · HCl |
| Assay | 97% |
| Melting point | 198-203 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride used for?
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It is used as a synthetic building block and pharmaceutical intermediate. Its 3-chloropropyl chain provides a reactive site for alkylation, letting chemists attach the 3-chlorophenylpiperazine unit to other molecules during fine-chemical and medicinal-chemistry synthesis. It is most commonly handled as an intermediate toward trazodone-type structures.
What is the CAS number and molecular formula of 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride?
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Its CAS number is 52605-52-4 and its empirical formula is C13H18Cl2N2 · HCl, with a molecular weight of 309.66 g/mol. Related identifiers include EC number 258-038-0, MDL number MFCD00067039 and PubChem Substance ID 24862198.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a minimum assay of 97% as a research and manufacturing-grade reagent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and full specifications are confirmed at the time of quotation.
What are the safety and handling precautions?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and use adequate ventilation (P261, P305+P351+P338). It carries German Water Hazard Class WGK 3, so prevent release into drains and watercourses. Always consult the SDS before use.
How is 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride packed, shipped and exported?
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It is packed as a solid in tightly closed, suitably lined containers sized from gram research quantities to larger commercial lots, with labelling and documentation prepared to applicable transport and export requirements. Tech Serve Solutions exports worldwide and provides the SDS and certificate of analysis with each shipment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, assay and packaging, and we will confirm availability, specification and lead time. Samples can be arranged for evaluation and qualification ahead of larger orders.
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