1-(2-Hydroxyethyl)-2-imidazolidinone solution
1-(2-Hydroxyethyl)-2-imidazolidinone (CAS 3699-54-5; C5H10N2O2; molar mass 130.15 g/mol) is a hydroxyethyl-substituted cyclic urea, also called 1-(hydroxyethyl)ethyleneurea. Tech Serve Solutions supplies it as a 75% aqueous solution (density 1.19 g/mL at 25 degrees C). This heterocyclic building block carries a free primary hydroxyl group on an imidazolidinone (ethyleneurea) ring, making it a versatile reagent for chemical synthesis and medicinal-chemistry research.
- IUPAC
- 1-(Hydroxyethyl)ethyleneurea,NSC 5775
- Synonyms
- 1-(2-Hydroxyethyl)-2-imidazolidinone1-(2-Hydroxyethyl)-2-imidazolidinone solution1-(Hydroxyethyl)ethyleneurea1-(2-Hydroxyethyl)ethyleneureaNSC 5775CAS 3699-54-5
Heterocyclic building block
Serves as an imidazolidinone (cyclic ethyleneurea) scaffold for chemical synthesis. The pendant primary hydroxyl group offers a convenient handle for further functionalisation, alkylation or coupling reactions.
Medicinal-chemistry reagent
Documented as a reagent in the synthesis of HIV-1 integrase inhibitors and as a reactant toward MDM2-p53 protein-protein interaction inhibitors. It supports the assembly of biologically targeted small molecules in discovery research.
Amino acid-derived heterocycles
Used as a reactant in routes to amino acid-derived heterocyclic compounds, where the imidazolidinone core contributes a constrained, polar ring system to the target structure.
CNS-targeted intermediates
Reported in the preparation of dopamine D-2 and serotonin 5-HT2 antagonists, supporting exploratory work on neuroactive compound classes.
| Molecular weight | 130.15 |
|---|---|
| Empirical formula | C5H10N2O2 |
| Density | 1.19 g/mL at 25 °C |
| Refractive index | n20/D 1.466 |
| Concentration | 75% in H2O |
| Application | Reagent for synthesis of HIV-1 integrase inhibitors1Reactant for synthesis of: MDM2-p53 protein-protein interaction inhibitors2 Amino acid-derived heterocycles3 dopamine D-2 and serotonin 5-HT2 antagonists4 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 1 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Hydroxyethyl)-2-imidazolidinone used for?
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It is used mainly as a heterocyclic building block and reagent for chemical synthesis. Documented uses include the synthesis of HIV-1 integrase inhibitors, MDM2-p53 protein-protein interaction inhibitors, amino acid-derived heterocycles, and dopamine D-2 and serotonin 5-HT2 antagonists. The hydroxyl-bearing imidazolidinone (ethyleneurea) ring makes it a useful scaffold for further functionalisation.
What is the CAS number and molecular formula of 1-(2-Hydroxyethyl)-2-imidazolidinone?
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The CAS number is 3699-54-5 and the molecular formula is C5H10N2O2, with a molecular weight of 130.15 g/mol. The MDL number is MFCD00037883. It is also known as 1-(hydroxyethyl)ethyleneurea and NSC 5775.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Hydroxyethyl)-2-imidazolidinone as a 75% solution in water (density 1.19 g/mL at 25 degrees C; refractive index n20/D 1.466), intended as a research and technical-grade reagent for synthesis. We do not represent it as USP, BP or EP pharmacopoeia grade. A current specification or certificate of analysis can be provided with your enquiry.
What are the safety and handling precautions?
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The product is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Recommended precautions include avoiding breathing dust, mist or vapour (P261) and, if in eyes, rinsing cautiously with water for several minutes and removing contact lenses if present (P305+P351+P338). Use suitable gloves, eye protection and adequate ventilation, and consult the Safety Data Sheet before handling. Its water hazard class is WGK 1 (Germany).
How is 1-(2-Hydroxyethyl)-2-imidazolidinone packed, shipped and exported?
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As an aqueous solution, it is packed in appropriate sealed bottles, drums or other suitable containers with full labelling and documentation. Tech Serve Solutions exports worldwide with the relevant Safety Data Sheet and certificate of analysis. Pack sizes and shipping arrangements can be tailored to your laboratory or production requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, pack size and destination, and our team will respond with availability, lead time and a quotation. As a specialist supplier and exporter of fine chemicals and reagents since 1998, we can also provide specification and documentation support.
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