1-(2-Furoyl)piperazine
1-(2-Furoyl)piperazine (CAS 40172-95-0; C9H12N2O2; molar mass 180.20 g/mol) is a crystalline heterocyclic building block in which a piperazine ring is acylated by a furan-2-carbonyl group. Supplied by Tech Serve Solutions at 97% assay, it is valued as a versatile intermediate for pharmaceutical and fine-chemical synthesis, most notably as a precursor in the preparation of quinazoline-type active ingredients. Its free secondary amine offers a convenient site for further functionalisation.
- IUPAC
- 2-Furoic piperazide
- Synonyms
- 1-(2-Furoyl)piperazine2-Furoic piperazide2-furyl(piperazin-1-yl)methanonefuran-2-yl(piperazin-1-yl)methanone1-(furan-2-carbonyl)piperazinepiperazine, 1-(2-furanylcarbonyl)-
Pharmaceutical intermediate
Used as a synthetic building block in the manufacture of active pharmaceutical ingredients and their intermediates. It is well documented as a key precursor in the synthesis of the quinazoline antihypertensive prazosin and related analogues.
Piperazine building block
The reactive secondary amine on the piperazine ring provides a ready handle for alkylation, acylation and reductive amination, making the compound a flexible scaffold for medicinal-chemistry and library synthesis.
Heterocyclic synthesis
Serves as a furan-carbonyl-bearing intermediate for constructing more elaborate nitrogen heterocycles and amide-linked structures in fine-chemical and discovery research.
Research and laboratory reagent
Employed as a reference and starting material in method development, structure-activity studies and other laboratory-scale chemical research.
| Molecular weight | 180.20 |
|---|---|
| Empirical formula | C9H12N2O2 |
| Assay | 97% |
| Melting point | 67-70 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Furoyl)piperazine used for?
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It is used chiefly as a fine-chemical and pharmaceutical building block. The piperazine ring carries a furan-2-carbonyl group and a free secondary amine, allowing further functionalisation; it is best known as an intermediate in the synthesis of the antihypertensive prazosin and related quinazoline compounds.
What is the CAS number and molecular formula of 1-(2-Furoyl)piperazine?
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The CAS number is 40172-95-0 and the molecular formula is C9H12N2O2, with a molecular weight of 180.20 g/mol. Related identifiers include EC number 254-823-7, MDL number MFCD00038831 and Beilstein registry number 880196.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Furoyl)piperazine at a minimum assay of 97%, as a research and technical-grade material with a reported melting point of 67-70 degrees C. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis accompanies each batch, and specifications can be confirmed against your requirements on request.
What are the safety and handling precautions for 1-(2-Furoyl)piperazine?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Avoid breathing dust and contact with skin and eyes; use an N95-type dust mask, eye protection and gloves (precautionary statements P261 and P305+P351+P338). Always consult the Safety Data Sheet before use.
How is 1-(2-Furoyl)piperazine packed, shipped and exported?
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It is packed as a solid in tightly closed, clearly labelled containers sized to suit laboratory through to commercial quantities, with packaging selected for the order volume and destination. As a global supplier and exporter since 1998, Tech Serve Solutions arranges export documentation, a certificate of analysis and Safety Data Sheet, and compliant international dispatch.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation and qualification where appropriate.
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