1,2-Bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate
1,2-Bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate (CAS: 136705-77-6) is a rhodium complex used as a privileged chiral catalyst in asymmetric synthesis. With a molecular weight of 722.62 g/mol and empirical formula C31H48F3O3P2RhS, it is integral to stereoselective transformations, including the synthesis of complex molecules like manzacidins and chiral amino acid derivatives through asymmetric hydrogenation.
- IUPAC
- (R,R)-Et-DUPHOS-Rh
- Synonyms
- 5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate136705-77-6C31H48F3O3P2RhS(R,R)-Et-DUPHOS-Rh
![1,2-Bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate (5R)-2) — chemical structure, CAS 136705-77-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F136705-77-6.png&w=3840&q=75)
Asymmetric Hydrogenation
Catalyst for the stereoselective synthesis of delta-amino acid derivatives via asymmetric hydrogenation of acetylaminopentenoic acid derivatives. It is also employed in the stereoselective synthesis of manzacidins A and C.
Chiral Molecule Synthesis
Facilitates the asymmetric preparation of chiral Cbz-aminodifluorobutyric acid methyl ester and its analogues. Enables the synthesis of the tetracyclic core of manzamine A.
Biphasic Hydrogenation
Utilised in biphasic catalytic hydrogenations within ionic liquids, with water serving as a co-solvent. This method offers advantages for catalyst separation and recycling.
| Molecular weight | 722.62 |
|---|---|
| Empirical formula | C31H48F3O3P2RhS |
| Application | DuPhos and BPE Ligands: Highly Efficient Privileged LigandsCatalyst for:• Stereoselective synthesis of δ-amino acid derivatives via asymmetric hydrogenation of acetylaminopentenoic acid derivatives1• Stereoselective synthesis of manzacidins A and C via stereoselective hydrogenation2• Stereoselective synthesis of tetracyclic core of manzamine A via Rh-catalyzed asymmetric hydrogenation, diastereoselective Diels-Alder reaction, Eschenmoser-Tanabe fragmentation, Chang′s amide formation, and Hofmann rearrangement3• Asymmetric preparation of chiral Cbz-aminodifluorobutyric acid Me ester and its analogs4• Biphasic catalytic hydrogenations in ionic liquids with addition of water as a second solvent5• Preparation of cyclo |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2-Bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate used for?
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This rhodium complex is primarily used as a catalyst in asymmetric synthesis, particularly for stereoselective hydrogenation reactions in the preparation of complex chiral molecules.
What are the CAS number and formula for this compound?
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The CAS number is 136705-77-6 and the empirical formula is C31H48F3O3P2RhS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with the available specifications as provided. We do not represent it as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product data.
What are the main safety concerns when handling this chemical?
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This compound is classified as a warning substance. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, and this product is available for export.
How can I request a sample or quote for this product?
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To request a sample or a quote, please use the contact form on our website or reach out to our sales team directly. Please reference the product name and CAS number (136705-77-6).
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