1,2-Bis(trimethylsiloxy)cyclobutene
1,2-Bis(trimethylsiloxy)cyclobutene (CAS: 17082-61-0) is an organosilicon compound with the molecular formula C10H22O2Si2 and a molecular weight of 230.45 g/mol. This enol ether is primarily utilised as a building block in complex organic synthesis. Its applications include the preparation of functionalised decalins for sesquiterpene and diterpene synthesis, and the construction of angularly substituted bicyclic diketones.
- Synonyms
- C10H22O2Si2
Synthesis of Functionalised Decalins
1,2-Bis(trimethylsiloxy)cyclobutene serves as a key intermediate in the total synthesis of various sesquiterpenes and diterpenes, enabling the construction of complex decalin frameworks.
Preparation of Bicyclic Diketones
The compound is employed in the synthesis of angularly substituted bicyclo[4.3.0]nona-2,5-diones and bicyclo[4.4.0]deca-2,5-diones, contributing to the diversity of carbocyclic frameworks.
Steroid Synthesis Intermediate
It has been utilised in synthetic routes towards compounds like 3-methoxyestra-1,3,5,8,14-pentaen-17-one, highlighting its role in steroid chemistry.
| Molecular weight | 230.45 |
|---|---|
| Empirical formula | C10H22O2Si2 |
| Assay | ≥95% |
| Boiling point | 58-59 °C/2 mmHg(lit.) |
| Density | 0.897 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.435(lit.) |
| Application | 1,2-Bis(trimethylsiloxy)cyclobutene has been used in the synthesis of:• functionalized decalins, required for the total synthesis of various sesquiterpenes and diterpenes1• angularly substituted bicyclo[4.3.0]nona-2,5-diones and bicyclo-[4.4.0]deca-2,5-diones2• 3-methoxyestra-1,3,5,8,14-pentaen-17-one3 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 61 °C / 141.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2-Bis(trimethylsiloxy)cyclobutene used for?
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1,2-Bis(trimethylsiloxy)cyclobutene is used as a building block in organic synthesis, particularly for preparing functionalised decalins, bicyclic diketones, and steroid intermediates.
What is the CAS number and formula for 1,2-Bis(trimethylsiloxy)cyclobutene?
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The CAS number is 17082-61-0 and the empirical formula is C10H22O2Si2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,2-Bis(trimethylsiloxy)cyclobutene with an assay of ≥95%. We do not represent this product as USP, BP, or EP grade.
How should 1,2-Bis(trimethylsiloxy)cyclobutene be handled safely?
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1,2-Bis(trimethylsiloxy)cyclobutene is classified as a Warning. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn. Ensure adequate ventilation.
Is 1,2-Bis(trimethylsiloxy)cyclobutene shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1,2-Bis(trimethylsiloxy)cyclobutene, and handles international shipments.
How can I request a sample or quote for 1,2-Bis(trimethylsiloxy)cyclobutene?
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Please contact the Tech Serve Solutions sales team directly to request a sample or a quotation for 1,2-Bis(trimethylsiloxy)cyclobutene.
How is 1,2-Bis(trimethylsiloxy)cyclobutene synthesized?
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Published preparations of 1,2-Bis(trimethylsiloxy)cyclobutene are documented in the chemical literature and patent records — see the synthesis and sourcing section on this page for reference links. Tech Serve Solutions supplies 1,2-Bis(trimethylsiloxy)cyclobutene ready to use; request a quote for current grades and pack sizes.
How 1,2-Bis(trimethylsiloxy)cyclobutene (17082-61-0) is synthesized — and where to buy it
1,2-Bis(trimethylsiloxy)cyclobutene is a strained-ring bis-silyl enediol ether used in ring-expansion and acyloin-derived syntheses. Like other silyl enol ethers it is moisture-sensitive.
Published synthesis & references
Why make it?
Silyl enol ethers hydrolyse on contact with ambient moisture, so material quality depends on freshness. We ship a fresh, assayed lot with a Certificate of Analysis.
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