Sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate
Sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate (CAS: 1049726-96-6) is a specialized phosphine ligand for palladium-catalyzed cross-coupling reactions. This sulfonated derivative offers enhanced solubility in aqueous media, facilitating efficient Suzuki-Miyaura coupling. Its structure allows for effective catalysis, leading to high yields in organic synthesis and is supplied by Tech Serve Solutions as a valuable reagent for chemical research and development.
- IUPAC
- SSPhos,SPhos (water soluble),[1,1′-Biphenyl]-3-sulfonic acid, 2′-(dicyclohexylphosphino)-2,6-dimethoxy- sodium salt
- Synonyms
- 1049726-96-6C26H34NaO5PS · xH2OSSPhos,SPhos (water soluble),[1,1′-Biphenyl]-3-sulfonic acid, 2′-(dicyclohexylphosphino)-2,6-dimethoxy- sodium salt
Suzuki-Miyaura Coupling
This ligand is specifically designed for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. Its sulfonated nature promotes solubility in aqueous conditions, simplifying reaction workup and product isolation.
Catalysis in Organic Synthesis
As a Buchwald ligand, it is instrumental in facilitating the formation of carbon-carbon bonds. It is particularly useful in complex molecule synthesis where mild reaction conditions and high functional group tolerance are required.
Aqueous Phase Catalysis
The hydrophilic sulfonate group makes this ligand suitable for reactions conducted in mixed aqueous-organic solvent systems. This can offer environmental benefits and improved reaction kinetics in certain applications.
| Molecular weight | 512.57 (anhydrous basis) |
|---|---|
| Empirical formula | C26H34NaO5PS · xH2O |
| Application | Sulfonated ligand for palladium-catalyzed Suzuki-Miyaura coupling under aqueous conditions facilitating isolation of the organic products.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Suzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate used for?
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This compound is primarily used as a sulfonated phosphine ligand in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions, particularly under aqueous conditions.
What is the CAS number and formula for this chemical?
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The CAS number is 1049726-96-6. The empirical formula is C26H34NaO5PS · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research-grade reagent. Purity details are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should Sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust. Ensure good ventilation. This compound is classified as an irritant to skin, eyes, and respiratory tract.
Is this product controlled or scheduled?
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The provided data does not indicate any controlled or scheduled substance status for this chemical.
How is this chemical typically packed and shipped?
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Tech Serve Solutions exports chemicals globally, ensuring appropriate packaging and documentation for safe and compliant international transport.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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