(Oxydi-2,1-phenylene)bis(diphenylphosphine)
(Oxydi-2,1-phenylene)bis(diphenylphosphine), CAS 166330-10-5, possesses a molecular weight of 538.55 g/mol. This sophisticated phosphine ligand is primarily employed as a critical component in various catalytic organic synthesis reactions. Its structure facilitates efficient metal coordination, making it valuable for promoting cross-coupling reactions and other complex transformations in pharmaceutical and fine chemical manufacturing.
- IUPAC
- Bis[(2-diphenylphosphino)phenyl] ether,DPEPhos
- Synonyms
- O[C6H4P(C6H5)2]2DPEPhosBis[(2-diphenylphosphino)phenyl] ether
![(Oxydi-2,1-phenylene)bis(diphenylphosphine) (O[C6H4P(C6H5)2]2) — chemical structure, CAS 166330-10-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F166330-10-5.png&w=3840&q=75)
Buchwald-Hartwig Cross Coupling Reactions
This ligand is highly effective in catalysing the formation of carbon-nitrogen and carbon-oxygen bonds, crucial for the synthesis of complex organic molecules found in pharmaceuticals and agrochemicals.
Suzuki-Miyaura Coupling
Utilised as a ligand in palladium-catalysed Suzuki-Miyaura coupling, it promotes the formation of carbon-carbon bonds, a fundamental transformation in organic synthesis for creating biaryl compounds.
Heck Reaction
The compound serves as an effective ligand in the Heck reaction, enabling the palladium-catalysed coupling of aryl or vinyl halides with alkenes to form substituted alkenes.
Negishi Coupling
It functions as a ligand in Negishi coupling reactions, facilitating the formation of carbon-carbon bonds between organozinc compounds and organohalides or triflates.
Hydroamination Catalysis
This phosphine ligand can be employed in catalytic hydroamination reactions, enabling the addition of N-H bonds across unsaturated substrates.
| Molecular weight | 538.55 |
|---|---|
| Linear formula | O[C6H4P(C6H5)2]2 |
| Assay | 98% |
| Melting point | 184-187 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Greener Alternative Product Characteristics | Catalysis |
|---|---|
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionHeck ReactionHydroaminationsNegishi CouplingSuzuki-Miyaura Coupling |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Oxydi-2,1-phenylene)bis(diphenylphosphine) used for?
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(Oxydi-2,1-phenylene)bis(diphenylphosphine) is used as a ligand in various metal-catalysed cross-coupling reactions, including Buchwald-Hartwig, Suzuki-Miyaura, Heck, and Negishi couplings, as well as in hydroaminations.
What is the CAS number and formula for (Oxydi-2,1-phenylene)bis(diphenylphosphine)?
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The CAS number is 166330-10-5 and the linear formula is O[C6H4P(C6H5)2]2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Oxydi-2,1-phenylene)bis(diphenylphosphine) at an assay of 98%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should (Oxydi-2,1-phenylene)bis(diphenylphosphine) be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. Refer to the Safety Data Sheet for comprehensive handling guidelines.
Is (Oxydi-2,1-phenylene)bis(diphenylphosphine) shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (Oxydi-2,1-phenylene)bis(diphenylphosphine), and can facilitate international shipping.
How can I request a sample or quote for (Oxydi-2,1-phenylene)bis(diphenylphosphine)?
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Please contact our sales team via the website or by phone to request a sample or a formal quotation for (Oxydi-2,1-phenylene)bis(diphenylphosphine).
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