Z-Glu(OtBu)-OH
Z-Glu(OtBu)-OH (CAS: 3886-08-6) is a protected amino acid derivative, specifically N-carbobenzyloxy-L-glutamic acid 5-tert-butyl ester. With a molecular weight of 337.37 g/mol, this compound serves as a crucial building block in organic synthesis, particularly in peptide chemistry. Its protected nature allows for selective reactions in complex molecular assembly, making it valuable for researchers in chemical biology and synthesis.
- IUPAC
- N-Cbz-L-glutamic acid γ-t-butyl ester,Z-L-glutamic acid 5-tert-butyl ester
- Synonyms
- N-Cbz-L-glutamic acid 5-tert-butyl esterZ-L-glutamic acid 5-tert-butyl ester
Peptide Synthesis
Z-Glu(OtBu)-OH is employed as a protected amino acid in solid-phase and solution-phase peptide synthesis. The tert-butyl ester protects the gamma-carboxyl group, enabling controlled coupling of other amino acids.
Organic Synthesis
This derivative is a versatile intermediate in the synthesis of complex organic molecules. Its distinct functional groups allow for regioselective modifications and incorporation into larger molecular scaffolds.
Chemical Biology Research
Used in research settings to construct peptides or peptidomimetics for studying biological processes. The protected nature facilitates its integration into probing or modifying biological systems.
| Molecular weight | 337.37 |
|---|---|
| Linear formula | (CH3)3COOCCH2CH2CH(NHCOOCH2C6H5)COOH |
| Assay | ≥99.0% (TLC) |
| Optical activity | [α]20/D −14±1°, c = 2% in methanol |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Z-Glu(OtBu)-OH used for?
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Z-Glu(OtBu)-OH is primarily used as a protected amino acid derivative in peptide synthesis and as an intermediate in general organic synthesis and chemical biology research.
What is the CAS number and molecular formula for Z-Glu(OtBu)-OH?
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The CAS number for Z-Glu(OtBu)-OH is 3886-08-6. The linear formula is (CH3)3COOCCH2CH2CH(NHCOOCH2C6H5)COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Z-Glu(OtBu)-OH with an assay of ≥99.0% (TLC). We do not represent this product as USP, BP, or EP grade.
How should Z-Glu(OtBu)-OH be handled safely?
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Z-Glu(OtBu)-OH is a warning-level substance, causing skin irritation (H315), allergic skin reaction (H317), serious eye irritation (H319), and respiratory irritation (H335). Always use recommended personal protective equipment including a dust mask (N95), eyeshields, face shield, and gloves. Ensure adequate ventilation.
Is Z-Glu(OtBu)-OH exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Z-Glu(OtBu)-OH.
How can I request a quote or sample for Z-Glu(OtBu)-OH?
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To request a quote or sample for Z-Glu(OtBu)-OH, please contact our sales team through the website or by phone.
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