Z-Gly-Bt
Z-Gly-Bt (CAS: 173459-80-8), with the molecular formula C16H14N4O3 and a molecular weight of 310.31 g/mol, is a derivative of glycine featuring a benzotriazole moiety. This compound serves as a versatile reagent in chemical synthesis, particularly in the field of peptide chemistry. It is instrumental in the preparation of various peptide analogues, conjugates, and peptidomimetics, finding applications in chemical biology research and drug discovery.
- IUPAC
- N-Z-(1-Benzotriazolylcarbonyl)methylamine,Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate
- Synonyms
- N-Z-(1-Benzotriazolylcarbonyl)methylamineBenzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate
Peptide Synthesis and Modification
Z-Gly-Bt functions as a key intermediate in the synthesis of peptides and peptidomimetics. It facilitates the formation of peptide bonds and allows for the introduction of benzotriazole functionalities into peptide chains.
Preparation of Conjugates
This compound is employed in creating peptide conjugates, enabling the linkage of peptides to other molecules such as fluorescent labels or various functional groups, which is valuable in biochemical and bioanalytical applications.
Synthesis of Peptidomimetics
Z-Gly-Bt is utilised in the construction of diverse peptidomimetic structures, including aminoxypeptides and depsipeptides, which are important for developing novel therapeutic agents with enhanced stability and efficacy.
| Molecular weight | 310.31 |
|---|---|
| Empirical formula | C16H14N4O3 |
| Assay | 97% |
| Storage temperature | −20°C |
| Application | Benzotriazole amino acids, or aminoacylbenzotriazolides, are versatile reagents for synthesizing peptides as well as their mimetics and conjugates. Benzotriazole amino acids have been used for the preparation of diverse derivatives including:• Polypeptidal benzotriazolides1• Peptidomimetics, such as aminoxypeptides2, depsipeptides3 and heterocyclic peptidomimetics4• Tagged peptides and peptidomimetics, particularly those with fluorescent labels5,6• N, O, S, and C linked peptide conjugates6 |
| Melting point | 110-117 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Z-Gly-Bt used for?
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Z-Gly-Bt is primarily used in chemical synthesis, particularly for the preparation of peptides, peptidomimetics, and peptide conjugates. It is a valuable tool in peptide chemistry and chemical biology.
What are the CAS number and molecular formula for Z-Gly-Bt?
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The CAS number for Z-Gly-Bt is 173459-80-8, and its molecular formula is C16H14N4O3.
What grade and purity does Tech Serve Solutions supply for Z-Gly-Bt?
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Tech Serve Solutions supplies Z-Gly-Bt with a purity of 97%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should Z-Gly-Bt be handled and stored?
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Z-Gly-Bt is classified with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). It should be handled with appropriate personal protective equipment in a well-ventilated area and stored at -20°C.
Can Tech Serve Solutions export Z-Gly-Bt?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Z-Gly-Bt, ensuring worldwide delivery.
How can I request a quote or sample for Z-Gly-Bt?
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To request a quote or a sample of Z-Gly-Bt, please contact our sales team through the website or by phone.
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