Y-27632 dihydrochloride
Y-27632 dihydrochloride (CAS: 129830-38-2) is a potent and selective Rho-kinase (ROCK) inhibitor. This white to beige powder, with the molecular formula C14H21N3O · 2HCl and a molecular weight of 320.26 g/mol, is commonly used in biological research. It plays a crucial role in studying cell signaling pathways, cell proliferation, and neuronal functions, particularly in neuroscience and cell biology applications.
- IUPAC
- (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride
Rho-Kinase (ROCK) Inhibition
Y-27632 dihydrochloride acts as a selective inhibitor of ROCK1 and ROCK2, making it invaluable for research into cellular processes regulated by these kinases, such as smooth muscle contraction and cell adhesion.
Cell Biology Research
This compound is widely employed in cell biology to investigate mechanisms of cell survival, apoptosis, and migration. Its use helps elucidate the roles of Rho-associated protein kinases in various cellular behaviours.
Neuroscience Studies
In neuroscience, Y-27632 dihydrochloride is used to study neuronal development, plasticity, and the effects of ROCK inhibition on neural circuits. It aids in understanding conditions affecting the nervous system.
Biochemical Assays
With an assay of ≥98% (HPLC), it serves as a reliable reagent in biochemical assays to quantify kinase activity or investigate drug discovery pathways involving ROCK.
| Molecular weight | 320.26 |
|---|---|
| Empirical formula | C14H21N3O · 2HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | H2O: soluble14 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ROCK1(6093), ROCK2(9475) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Y-27632 dihydrochloride used for?
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Y-27632 dihydrochloride is primarily used as a selective Rho-kinase (ROCK) inhibitor in biological research, particularly in cell biology, neuroscience, and for studying cell signaling pathways.
What is the CAS number and molecular formula for Y-27632 dihydrochloride?
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The CAS number for Y-27632 dihydrochloride is 129830-38-2, and its molecular formula is C14H21N3O · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Y-27632 dihydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Y-27632 dihydrochloride be handled safely?
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Y-27632 dihydrochloride is classified with GHS07 and a Warning signal word. Hazard statements include H302, H312, and H332 (Harmful if swallowed, in contact with skin, or if inhaled). Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
How is Y-27632 dihydrochloride typically supplied and exported?
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Y-27632 dihydrochloride is supplied as a white to beige powder and stored at 2-8°C. As a specialist global supplier and exporter, TSS ensures proper packaging and documentation for international shipments.
How can I request a sample or quote for Y-27632 dihydrochloride?
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To request a sample or a quote for Y-27632 dihydrochloride, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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