Tris(phenylthio)methane
Tris(phenylthio)methane (CAS 4832-52-4), also known as triphenyl trithioorthoformate, is an organic sulfur compound with the linear formula (C6H5S)3CH. This chemical is primarily utilized as a building block in organic synthesis. Its applications include the preparation of 1-phenylthio-tetrahydroisoquinolines and homoallylchalcogenoacetals, making it valuable for researchers in specialized chemical synthesis and the development of complex organic molecules.
- IUPAC
- Triphenyl trithioorthoformate
- Synonyms
- Triphenyl trithioorthoformate

Preparation of 1-Phenylthio-tetrahydroisoquinolines
Utilized in the activated Pictet-Spengler cyclization to synthesise these heterocyclic compounds.
Synthesis of Homoallylchalcogenoacetals
Reacts with allylsilanes in the presence of a Lewis acid to form these sulfur-containing acetals.
Organic Synthesis Building Block
Serves as a versatile intermediate in the construction of more complex organic molecules.
| Molecular weight | 340.53 |
|---|---|
| Linear formula | (C6H5S)3CH |
| Assay | 98% |
| Application | Tris(phenylthio)methane has been used in the preparation of:• 1-phenylthio-tetrahydroisoquinolines via activated Pictet-Spengler cyclization1• homoallylchalcogenoacetals via reaction with allylsilanes in the presence of a Lewis acid2 |
| Melting point | 39-41 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3335 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(phenylthio)methane used for?
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Tris(phenylthio)methane is used as a building block in organic synthesis, particularly for preparing compounds like 1-phenylthio-tetrahydroisoquinolines and homoallylchalcogenoacetals.
What is the CAS number and formula for Tris(phenylthio)methane?
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The CAS number is 4832-52-4, and its linear formula is (C6H5S)3CH.
What is the purity of Tris(phenylthio)methane supplied by TSS?
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This product is supplied at an assay of 98%.
What are the primary hazards associated with Tris(phenylthio)methane?
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Tris(phenylthio)methane is classified as a Warning, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
How is Tris(phenylthio)methane packed and shipped?
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It is shipped according to relevant transport regulations (UN 3335). Specific packing details can be provided upon request.
Can TSS export Tris(phenylthio)methane globally?
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Yes, as a specialist global supplier and exporter, TSS can arrange worldwide export of Tris(phenylthio)methane.
How can I request a quote for Tris(phenylthio)methane?
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To request a quote, please contact our sales department with your specific requirements.
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