Tris(tert-butyldimethylsilyl) phosphite
Tris(tert-butyldimethylsilyl) phosphite (CAS 85197-27-9, C18H45O3PSi3) is a silicon-protected phosphite ester with a molecular weight of 424.78. It serves as a valuable building block in organic synthesis, particularly in reactions where phosphite functionalities are required. Its unique structure makes it useful for introducing phosphorus-containing groups in complex molecular architectures. Available from Tech Serve Solutions, it is supplied for laboratory and research applications.

Organic Synthesis Reagent
This compound functions as a versatile reagent in organic synthesis, enabling the introduction of protected phosphite moieties. Its silyl groups offer protection and can be selectively removed under specific conditions.
Phosphorus Chemistry
As a phosphorus-containing compound, it is instrumental in the synthesis of novel organophosphorus compounds. These derivatives find applications in materials science and medicinal chemistry research.
Building Block for Complex Molecules
Tris(tert-butyldimethylsilyl) phosphite acts as a key building block for constructing complex organic molecules. Its structure facilitates controlled P-C bond formation in various synthetic pathways.
| Molecular weight | 424.78 |
|---|---|
| Empirical formula | C18H45O3PSi3 |
| Assay | ≥97.0% |
| Boiling point | 82-84 °C/0.2 mmHg |
| Density | 0.907 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.445 |
| Melting point | 4-6 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(tert-butyldimethylsilyl) phosphite used for?
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Tris(tert-butyldimethylsilyl) phosphite is used as a reagent in organic synthesis for introducing protected phosphite groups and as a building block for complex organophosphorus compounds.
What is the CAS number and formula for Tris(tert-butyldimethylsilyl) phosphite?
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The CAS number is 85197-27-9 and the empirical formula is C18H45O3PSi3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris(tert-butyldimethylsilyl) phosphite with an assay of ≥97.0%. It is supplied for research and laboratory use and is not represented as USP, BP, or EP grade.
How should Tris(tert-butyldimethylsilyl) phosphite be handled?
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This compound is corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection. Ensure adequate ventilation and immediate access to emergency equipment.
How is Tris(tert-butyldimethylsilyl) phosphite packed and shipped?
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Tris(tert-butyldimethylsilyl) phosphite is packed in compliance with regulations for hazardous materials, identified as UN 3265, Class 8, PGIII. We export globally, adhering to all international shipping standards for dangerous goods.
How can I request a quote or sample?
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To request a quote or a sample of Tris(tert-butyldimethylsilyl) phosphite, please contact our sales department via the website or direct email, providing your contact details and desired quantity.
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