Tris[2-(2-methoxyethoxy)ethyl]amine
Tris[2-(2-methoxyethoxy)ethyl]amine (CAS 70384-51-9) is a tertiary amine with a molecular weight of 323.43 g/mol. This organic compound, featuring multiple ether linkages and a central nitrogen atom, functions effectively as a phase-transfer catalyst and cryptand in various chemical syntheses. Its properties make it a valuable reagent in oxidation reactions and the synthesis of complex nucleoside analogues.
- IUPAC
- TDA-1,Tris(3,6-dioxaheptyl)amine
- Synonyms
- TDA-1Tris(3,6-dioxaheptyl)amine
![Tris[2-(2-methoxyethoxy)ethyl]amine ((CH3OCH2CH2OCH2CH2)3N) — chemical structure, CAS 70384-51-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F70384-51-9.png&w=3840&q=75)
Phase-Transfer Catalysis
Tris[2-(2-methoxyethoxy)ethyl]amine is employed as a phase-transfer catalyst in organic synthesis, notably in the preparation of nucleoside analogues such as 1,3-dideaza-2′-deoxyadenosine.
Oxidation Reactions
This amine serves as a catalyst in the oxidation of arylmethanols under phase-transfer conditions, facilitating efficient conversion of these substrates.
Glycosylation Reactions
It acts as a cryptand in phase-transfer glycosylation reactions, exemplified by its use in the synthesis of 2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine derivatives.
| Molecular weight | 323.43 |
|---|---|
| Linear formula | (CH3OCH2CH2OCH2CH2)3N |
| Assay | 95% |
| Density | 1.011 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4486(lit.) |
| Application | Tris[2-(2-methoxyethoxy)ethyl]amine was used:• in oxidation of arylmethanols under phase-transfer conditions1• as cryptand during phase-transfer glycosylation of 2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine2• as phase-transfer catalyst in synthesis of 1,3-dideaza-2′-deoxyadenosine and related benzimidazole 2′-deoxyribonucleosides3 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 162 °C / 323.6 °F |
| Transport (UN / ADR) | UN 2735 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris[2-(2-methoxyethoxy)ethyl]amine used for?
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Tris[2-(2-methoxyethoxy)ethyl]amine is primarily used as a phase-transfer catalyst and cryptand in organic synthesis, including oxidation reactions and the preparation of nucleoside analogues.
What are the CAS number and formula for Tris[2-(2-methoxyethoxy)ethyl]amine?
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The CAS number is 70384-51-9, and its linear formula is (CH3OCH2CH2OCH2CH2)3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris[2-(2-methoxyethoxy)ethyl]amine at an assay of 95%. We do not represent this product as USP, BP, or EP grade.
How should Tris[2-(2-methoxyethoxy)ethyl]amine be handled safely?
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Tris[2-(2-methoxyethoxy)ethyl]amine is classified as Danger with H314 hazard statement (Causes severe skin burns and eye damage). Handle with appropriate personal protective equipment, including faceshields, gloves, and respirators, and follow stringent safety protocols.
How is Tris[2-(2-methoxyethoxy)ethyl]amine packed and shipped?
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This chemical is shipped as UN 2735, Class 8, Packing Group III. It is exported globally by Tech Serve Solutions following all relevant transport regulations.
How can I request a sample or quote?
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To request a sample or obtain a quote for Tris[2-(2-methoxyethoxy)ethyl]amine, please contact our sales team through our website or direct email.
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