Tolbutamide
Tolbutamide (CAS 64-77-7, C12H18N2O3S) is a sulfonylurea compound with a molecular weight of 270.35 g/mol. Historically used as an oral hypoglycemic agent, it is now primarily employed in research settings and as an analytical standard. This compound is valuable for studies in drug metabolism, cell signalling pathways, and as a reference material in chromatography and bioanalysis.
- IUPAC
- 1-Butyl-3-(4-methylphenylsulfonyl)urea
- Synonyms
- 1-Butyl-3-(4-methylphenylsulfonyl)urea
Analytical Standard
Tolbutamide serves as a certified reference material for chromatographic techniques like HPLC. It is essential for calibrating instruments and validating analytical methods in pharmaceutical quality control and research laboratories.
Research Chemical
Used in biochemical and cell biology research to investigate drug metabolism pathways, particularly concerning cytochrome P450 enzymes. Its effects on cell signalling are also a focus of study.
Drug Metabolism Studies
Investigating the metabolic fate of Tolbutamide, including its interaction with enzymes like CYP1A2 and CYP2C9, aids in understanding xenobiotic metabolism and drug-drug interactions.
| Molecular weight | 270.35 |
|---|---|
| Empirical formula | C12H18N2O3S |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ALB(213), CYP1A2(1544), CYP2C9(1559), EPHX2(2053), KCNJ1(3758)mouse ... Ephx2(13850) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tolbutamide (CAS 64-77-7) used for?
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Tolbutamide (CAS 64-77-7) is used as an analytical standard for chromatographic techniques and in biochemical research, particularly for studying drug metabolism and cell signalling pathways.
What are the CAS number and formula for Tolbutamide?
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The CAS number for Tolbutamide is 64-77-7, and its molecular formula is C12H18N2O3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tolbutamide typically as a research grade chemical. The specific assay and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
What are the safety and handling precautions for Tolbutamide?
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Tolbutamide requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures. The WGK (German water hazard class) is 2.
Is Tolbutamide a controlled substance?
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Based on the provided data, Tolbutamide is not listed as a controlled substance. However, users should always comply with local regulations.
How is Tolbutamide packed, shipped, and exported?
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Tolbutamide is carefully packed to ensure stability during transit. Tech Serve Solutions is experienced in exporting chemicals globally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for Tolbutamide?
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To request a sample or a quotation for Tolbutamide, please use the contact form on our website or reach out to our sales department directly.
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