rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl
rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl (CAS 255836-67-0) is a chiral phosphine ligand with the molecular formula C28H31P and a molecular weight of 398.52 g/mol. This compound is recognised for its utility in homogeneous catalysis, particularly within Buchwald-Hartwig amination and related cross-coupling reactions. It is widely employed in synthetic organic chemistry for facilitating the formation of carbon-heteroatom bonds under mild conditions, contributing to efficient chemical synthesis.
- IUPAC
- TrixiePhos
- Synonyms
- rac-2-(Di-tert-butylphosphino)-1,1′-binaphthylTrixiePhos
Catalysis in Organic Synthesis
This phosphine ligand is a key component in transition metal-catalysed cross-coupling reactions, such as the Buchwald-Hartwig amination. It enables the efficient formation of C-N, C-O, and C-S bonds, crucial for constructing complex organic molecules.
Ligand for Palladium Catalysis
As a bulky, electron-rich phosphine ligand, it stabilises palladium intermediates and promotes high catalytic activity and selectivity in various coupling processes. Its structure is tailored for challenging substrates.
Synthesis of Pharmaceutical Intermediates
The compound facilitates synthetic routes to complex molecules, including active pharmaceutical ingredients (APIs) and their precursors. Its application aids in the development of novel therapeutic agents.
| Molecular weight | 398.52 |
|---|---|
| Empirical formula | C28H31P |
| Assay | 97% |
| Melting point | 144-148 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl used for?
+
rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl is primarily used as a chiral phosphine ligand in homogeneous catalysis, especially for palladium-catalysed cross-coupling reactions like the Buchwald-Hartwig amination. It facilitates the formation of carbon-heteroatom bonds in organic synthesis.
What are the CAS number and formula for rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl?
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The CAS number for rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl is 255836-67-0, and its empirical formula is C28H31P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl with an assay of 97%. This product is typically supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl be handled?
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rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, avoid breathing dust, and ensure adequate ventilation. In case of eye contact, rinse cautiously with water for several minutes and seek medical advice.
Is this chemical packed and shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl. We adhere to international shipping regulations for chemical products.
How can I request a quote or sample?
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To request a quote or a sample of rac-2-(Di-tert-butylphosphino)-1,1′-binaphthyl, please visit our website or contact our sales department directly through the provided contact information.
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