tBuBrettPhos
tBuBrettPhos (CAS: 1160861-53-9), with the chemical formula C31H49O2P and a molecular weight of 484.69 g/mol, is a highly effective phosphine ligand. It is extensively employed in modern organic synthesis, particularly in catalysing challenging cross-coupling reactions. Its sophisticated structure enables efficient formation of carbon-heteroatom bonds, making it a valuable reagent in pharmaceutical research and fine chemical production.
- IUPAC
- 2-(Di-tert-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl,t-Bu Brett Phos,t-BuBrett Phos,t-BuBrett-Phos,t-BuBrettPhos,[3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl) [1,1′-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine,tert-ButylBrettPhos,tertButylBrettPhos
- Synonyms
- t-Bu Brett Phost-BuBrettPhost-BuBrett-Phost-BuBrettPhos[3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl) [1,1′-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphinetert-ButylBrettPhostertButylBrettPhos
Buchwald-Hartwig Amination and Arylation
tBuBrettPhos serves as a key ligand in palladium-catalysed cross-coupling reactions, facilitating the formation of C-N and C-O bonds. It is highly effective in arylating amines and alcohols under mild conditions.
C-X Bond Formation
This ligand is instrumental in catalysing the formation of carbon-heteroatom bonds (C-X), including C-F, C-Cl, and C-Br bonds. Its efficacy is particularly noted in difficult coupling scenarios.
Fluorination Reactions
In organic synthesis, tBuBrettPhos enables efficient palladium-catalysed fluorination reactions. It facilitates the introduction of fluorine atoms into organic molecules, a critical transformation in drug discovery.
Catalysis in Chemical Synthesis
As a member of the Buchwald phosphine ligand family, tBuBrettPhos is a versatile catalyst component for a wide array of synthetic transformations. Its unique steric and electronic properties promote high catalytic activity and selectivity.
| Molecular weight | 484.69 |
|---|---|
| Empirical formula | C31H49O2P |
| Assay | 97% |
| Application | Buchwald Phosphine Ligands for chemical Synthesis |
| Melting point | 166-170 °C |
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionC-X Bond FormationFluorinations |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tBuBrettPhos used for?
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tBuBrettPhos is used as a phosphine ligand in palladium-catalysed cross-coupling reactions such as Buchwald-Hartwig amination, arylation, C-X bond formation, and fluorination reactions for chemical synthesis.
What is the CAS number and formula for tBuBrettPhos?
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The CAS number for tBuBrettPhos is 1160861-53-9, and its chemical formula is C31H49O2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tBuBrettPhos with a minimum assay of 97%. This product is intended for laboratory research and development and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should tBuBrettPhos be handled?
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tBuBrettPhos is classified under GHS09 (Environmentally Hazardous). Handle with care to prevent release into the environment. Refer to the Safety Data Sheet (SDS) for detailed handling, storage, and disposal information. It has a melting point of 166-170 °C.
How is tBuBrettPhos packed and shipped?
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Tech Serve Solutions professionally packs and ships chemicals globally. Specific packing configurations and export documentation are handled according to regulatory requirements and customer needs.
How can I request a sample or quote for tBuBrettPhos?
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To request a sample or a quotation for tBuBrettPhos, please contact our sales team via the website or email, providing your specific requirements and shipping details.
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