t-BuDavePhos
t-BuDavePhos (CAS: 224311-49-3), with the molecular formula C22H32NP and a molecular weight of 341.47 g/mol, is a phosphine ligand crucial for cross-coupling reactions. It is widely employed in organic synthesis, particularly for the formation of carbon-carbon and carbon-heteroatom bonds. This compound is recognised for its effectiveness in catalysing challenging arylations and related transformations, facilitating efficient synthesis pathways in research and development.
- IUPAC
- 2′-(Di-tert-butylphosphino)-N,N-dimethylbiphenyl-2-amine,2-Di-tert-butylphosphino-2′-(N,N-dimethylamino)biphenyl,t-Butyl DavePhos,tBuDavePhos
- Synonyms
- 2′-(Di-tert-butylphosphino)-N,N-dimethylbiphenyl-2-amine2-Di-tert-butylphosphino-2′-(N,N-dimethylamino)biphenylt-Butyl DavePhostBuDavePhos
Buchwald-Hartwig Amination
t-BuDavePhos serves as an effective ligand in palladium-catalysed Buchwald-Hartwig amination reactions. It facilitates the formation of C-N bonds by coupling aryl halides or pseudohalides with amines.
Suzuki-Miyaura Cross-Coupling
This ligand is utilised in Suzuki-Miyaura cross-coupling reactions, enabling the formation of C-C bonds between organoboron compounds and organic halides or pseudohalides. It is particularly useful for coupling sterically hindered substrates.
C-X Bond Formation
t-BuDavePhos is instrumental in various C-X bond forming reactions, including C-O and C-S bond formations. Its electron-rich nature and bulky tert-butyl groups promote catalytic activity and selectivity.
Catalysis in Organic Synthesis
As a sophisticated phosphine ligand, t-BuDavePhos is a key component in advanced catalytic systems. It enhances the efficiency and scope of numerous organic transformations vital to pharmaceutical and materials science research.
| Molecular weight | 341.47 |
|---|---|
| Empirical formula | C22H32NP |
| Assay | 97% |
| Melting point | 114-118 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionC-X Bond Formation |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is t-BuDavePhos used for?
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t-BuDavePhos is primarily used as a ligand in palladium-catalysed cross-coupling reactions, such as Buchwald-Hartwig amination and Suzuki-Miyaura coupling, for the efficient formation of C-C, C-N, C-O, and C-S bonds.
What is the CAS number and molecular formula for t-BuDavePhos?
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The CAS number for t-BuDavePhos is 224311-49-3, and its molecular formula is C22H32NP.
What grade and purity does Tech Serve Solutions supply for t-BuDavePhos?
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Tech Serve Solutions supplies t-BuDavePhos with a minimum assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should t-BuDavePhos be handled and stored?
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t-BuDavePhos is classified as a Warning substance (GHS07), with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). It may also cause long-lasting harmful effects to aquatic life (H413). Handle with appropriate personal protective equipment including a dust mask (type N95), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. Store in a cool, dry place.
Is t-BuDavePhos available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including t-BuDavePhos. We can arrange shipment to customers worldwide, adhering to all relevant regulations.
How can I request a sample or quote for t-BuDavePhos?
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To request a sample or a quote for t-BuDavePhos, please contact our sales team through the website or by phone. Provide your details and the required quantity.
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