tBuXPhos
tBuXPhos (CAS: 564483-19-8), a vital phosphine ligand with the molecular formula C29H45P and a molecular weight of 424.64 g/mol, is extensively employed in palladium-catalyzed cross-coupling reactions. Its primary application lies in facilitating the formation of carbon-oxygen (C-O) and carbon-nitrogen (C-N) bonds. Available from Tech Serve Solutions (TSS) with a minimum assay of 97%, tBuXPhos is an essential reagent for advanced organic synthesis and pharmaceutical intermediate development.
- IUPAC
- 2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl,t-Bu XPhos,tBuXPhos,tert-Butyl XPhos
- Synonyms
- 2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenylt-Bu XPhostBuXPhostert-Butyl XPhos
Palladium-Catalyzed C-O and C-N Bond Formation
tBuXPhos serves as a highly effective ligand in palladium-catalyzed reactions, promoting the formation of aryl ethers and arylamines. Its steric and electronic properties enable efficient coupling under various conditions.
Buchwald-Hartwig Amination and Arylation
This ligand is a key component in Buchwald-Hartwig amination and related arylations, enabling the synthesis of complex amine and ether structures. It is particularly useful for coupling challenging substrates.
Cross-Coupling Reactions
tBuXPhos is a versatile ligand for a range of cross-coupling reactions, including arylations, carboxylations, and decarboxylations. Its robustness contributes to high yields and catalyst turnover.
| Molecular weight | 424.64 |
|---|---|
| Empirical formula | C29H45P |
| Assay | 97% |
| Application | Ligands for Pd-catalyzed C-O and C-N bond formation. |
| Melting point | 148-151 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionCarboxylationsDecarboxylations |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tBuXPhos used for?
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tBuXPhos is primarily used as a ligand in palladium-catalyzed reactions for C-O and C-N bond formation, as well as other cross-coupling reactions like arylations, carboxylations, and decarboxylations.
What are the CAS number and molecular formula for tBuXPhos?
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The CAS number for tBuXPhos is 564483-19-8, and its molecular formula is C29H45P.
What grade and purity does Tech Serve Solutions supply for tBuXPhos?
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Tech Serve Solutions supplies tBuXPhos with a minimum assay of 97%. This product is intended for research and development purposes, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should tBuXPhos be handled safely?
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When handling tBuXPhos, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. The compound is classified with a WGK Germany of 3, indicating it is hazardous to water.
Can tBuXPhos be exported or shipped in development quantities for research?
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Yes, Tech Serve Solutions specialises in supplying and exporting fine chemicals like tBuXPhos in development quantities for research purposes globally.
How can I request a quote or sample for tBuXPhos?
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To request a quote or sample for tBuXPhos, please contact our sales team through the website or by phone. Our experts will assist you with your inquiry.
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