Tolnaftate

CAS 2398-96-1C19H17NOSBiochemicals & Reagents

Tolnaftate (CAS: 2398-96-1) is a synthetic thiocarbamate with the molecular formula C19H17NOS and a molecular weight of 307.41 g/mol. It functions by inhibiting squalene epoxidase, a key enzyme in ergosterol biosynthesis. Clinically, Tolnaftate is recognised for its efficacy in treating superficial fungal infections such as athlete's foot, jock itch, and ringworm. It also serves as a valuable comparator in antifungal research.

IUPAC: Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
Synonyms: Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester

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Tolnaftate (C19H17NOS) — chemical structure, CAS 2398-96-1; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics T-ZAntifungalBiochemicals and ReagentsSpectrum of Activity More...

01 /Applications

Antifungal Treatment

Tolnaftate is a clinically approved topical antifungal agent used to treat common cutaneous mycoses including tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm).

Mechanism of Action Studies

This compound is employed in research to investigate the intricate pathways of ergosterol biosynthesis, specifically by inhibiting the rate-limiting enzyme, squalene epoxidase.

Antifungal Efficacy Comparison

Tolnaftate is frequently utilised as a reference or comparator compound in studies designed to evaluate the antifungal efficacy of novel agents.

02 /Properties

Molecular weight	307.41
Empirical formula	C19H17NOS
Storage temperature	2-8°C
Application	Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm1. It also has been used as a comparator compound for antifungal efficiency studies2.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2398-96-1

MDL number

MFCD00056611

PubChem substance

24900394

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Tolnaftate used for?

Tolnaftate is primarily used for the topical treatment of common superficial fungal skin infections such as athlete's foot, jock itch, and ringworm. It is also used in research to study ergosterol biosynthesis inhibition and as a comparator for antifungal efficacy.

What is the CAS number and molecular formula for Tolnaftate?

The CAS number for Tolnaftate is 2398-96-1, and its molecular formula is C19H17NOS.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tolnaftate. The specific grade and purity are detailed in the product's Certificate of Analysis. TSS does not represent this product as USP, BP, or EP grade unless explicitly stated in the product data.

How should Tolnaftate be handled and stored?

Handle Tolnaftate with appropriate personal protective equipment, including eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) is recommended. Store at 2-8°C.

Is Tolnaftate a controlled substance?

The provided data does not indicate that Tolnaftate is a controlled substance.

How is Tolnaftate packed, shipped, and exported?

Tolnaftate is carefully packed according to industry standards to ensure safe transit. Tech Serve Solutions is experienced in exporting fine chemicals globally.