Timolol maleate salt
Timolol maleate salt (CAS: 26921-17-5), with the empirical formula C13H24N4O3S · C4H4O4 and a molecular weight of 432.49 g/mol, is a white to off-white powder. This adrenergic beta-blocker is primarily recognised for its applications in cardiovascular research, including evaluating cardiac functions and ion transport in cellular models. Its solubility in both water and ethanol facilitates its use in various experimental setups.
- IUPAC
- S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt,Timolol hydrogen maleate
- Synonyms
- S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate saltTimolol hydrogen maleate
Cardiovascular Function Evaluation
Timolol maleate salt has been employed in preclinical research to assess cardiovascular functions in animal models, such as mice.
Cardiac Ion Transport Studies
It serves as a research tool for investigating the uptake of ions, like 86Rb+, in cellular components such as rat cardiomyocytes.
Pharmacological Research
As an adrenergic antagonist, it is utilized in studies focusing on beta-adrenergic receptor activity and its downstream effects in biological systems.
| Molecular weight | 432.49 |
|---|---|
| Empirical formula | C13H24N4O3S · C4H4O4 |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: solubleethanol: soluble |
| Optical activity | [α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.) |
| Melting point | 202-203 °C(lit.) |
| Application | Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6. |
Hazard statements
- H302Harmful if swallowed
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 63-22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ADRB1(153), ADRB2(154), ADRB3(155) |
|---|---|
| Absorption | ε1M/294 nm 8,700 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Timolol maleate salt used for?
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Timolol maleate salt is used in research for evaluating cardiovascular functions and studying ion transport mechanisms, particularly within cardiac cells. It acts as an adrenergic beta-blocker.
What are the CAS number and formula for Timolol maleate salt?
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The CAS number for Timolol maleate salt is 26921-17-5, and its empirical formula is C13H24N4O3S · C4H4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Timolol maleate salt with an assay of ≥98% (TLC). TSS does not represent this product as USP, BP, or EP grade.
How should Timolol maleate salt be handled safely?
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Timolol maleate salt is classified with a GHS07 and GHS08 symbol and a Warning signal word, carrying hazard statements H302 (harmful if swallowed) and H361 (suspected of damaging fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respirators, should be used.
Is Timolol maleate salt shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Timolol maleate salt.
How can I request a quote or sample?
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To request a quote or sample of Timolol maleate salt, please contact our sales team through the website or via the provided contact information.
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